5,6-dimethyl-1-(4-nitro-benzyl)-2-(4-nitro-phenyl)-1H-benzo[d]imidazole | 1418265-66-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5,6-dimethyl-1-(4-nitro-benzyl)-2-(4-nitro-phenyl)-1H-benzo[d]imidazole
• 英文别名: 5,6-Dimethyl-2-(4-nitrophenyl)-1-[(4-nitrophenyl)methyl]benzimidazole；5,6-dimethyl-2-(4-nitrophenyl)-1-[(4-nitrophenyl)methyl]benzimidazole
• CAS: 1418265-66-3
• 化学式: C₂₂H₁₈N₄O₄
• 分子量: 402.409
• InChiKey: LPDSGEBHOUXHFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  110
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 、 4，5-二甲基-1，2-苯二胺 在 alumina supported sulfuric acid 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以85%的产率得到5,6-dimethyl-1-(4-nitro-benzyl)-2-(4-nitro-phenyl)-1H-benzo[d]imidazole
  参考文献：
  名称：

  Eco-friendly synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles using alumina-sulfuric acid as a heterogeneous reusable catalyst

  摘要：

  A cost-effective and eco-friendly synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles has been developed through the condensation of different aldehydes with o-phenylenediamine using alumina-sulfuric acid as a recyclable heterogeneous solid acid catalyst. Morphological properties of the catalyst have been investigated. Effect of different solvents and comparison of alumina-sulfuric acid with different acid catalysts have also been studied. A plausible mechanistic pathway has been proposed on the basis of the isotope labelling experiments where catalytic behaviour of alumina-sulfuric acid has been explained. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.125

文献信息

• Eco-friendly synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles using alumina-sulfuric acid as a heterogeneous reusable catalyst
  作者：Amit Pramanik、Rimi Roy、Sagar Khan、Avishek Ghatak、Sanjay Bhar

  DOI：10.1016/j.tetlet.2014.01.125

  日期：2014.3

  A cost-effective and eco-friendly synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles has been developed through the condensation of different aldehydes with o-phenylenediamine using alumina-sulfuric acid as a recyclable heterogeneous solid acid catalyst. Morphological properties of the catalyst have been investigated. Effect of different solvents and comparison of alumina-sulfuric acid with different acid catalysts have also been studied. A plausible mechanistic pathway has been proposed on the basis of the isotope labelling experiments where catalytic behaviour of alumina-sulfuric acid has been explained. (C) 2014 Elsevier Ltd. All rights reserved.