(SS)-N-Acetylphenylalanylphenylalaninol | 57449-34-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (SS)-N-Acetylphenylalanylphenylalaninol
• 英文别名: N-Acetyl-L-phenylalanyl-L-phenylalaninol；(2S)-2-acetamido-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-phenylpropanamide
• CAS: 57449-34-0
• 化学式: C₂₀H₂₄N₂O₃
• 分子量: 340.422
• InChiKey: QYCOUYBBIYYCBB-OALUTQOASA-N

物化性质

• 沸点：
  663.0±55.0 °C(Predicted)
• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2S)-2-acetamido-3-phenyl-N-[(2S)-1-phenyl-3-phenylmethoxypropan-2-yl]propanamide 生成 (SS)-N-Acetylphenylalanylphenylalaninol
  参考文献：
  名称：

  OJIMA, IWAO;YATABE, MOMOKO, CHEM. LETT., 1982, N 9, 1335-1338

  摘要：

  DOI：

文献信息

• SYNTHESIS OF OPTICALLY ACTIVE<i>N</i>-[(<i>N</i>-ACETYL)-α-AMINOACYL]-β-AMINO ALCOHOLS BY HOMOGENEOUS AND HETEROGENEOUS ASYMMETRIC HYDROGENATIONS
  作者：Iwao Ojima、Momoko Yatabe

  DOI：10.1246/cl.1982.1335

  日期：1982.9.5

  Asymmetric hydrogenations of N-(N-acetyldehydrophenylalanyl)-β-amino alcohol benzyl ethers were carried out by using either rhodium complexes with chiral and achiral phosphines or 10% palladium on carbon. The effects of the chiral center in the β-amino alcohol moiety on simple as well as double asymmetric induction are described.

  N-(N-乙酰脱氢苯丙氨酰基)-β-氨基醇苄基醚的不对称氢化通过使用铑与手性和非手性膦的配合物或10%钯碳进行。描述了 β-氨基醇部分中的手性中心对简单和双重不对称诱导的影响。
• TRANSFORMANT PRODUCING SECONDARY METABOLITE MODIFIED WITH FUNCTIONAL GROUP AND NOVEL BIOSYNTHESIS GENES
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1223215A1

  公开（公告）日：2002-07-17

  An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nitrogen atom. A transformant according to the present invention is a transformant of an organism producing a secondary metabolite having a benzene ring skeleton without substitution at the para-position with a functional group containing a nitrogen atom, said transformant being transformed by introducing a gene involved in a biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid so as to produce a secondary metabolite having a benzene ring skeleton substituted at the para-position with a functional group containing a nitrogen atom. Another objective of the present invention is to provide a novel gene involved in the biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid. A novel gene according to the present invention comprises genes encoding the amino acid sequences of SEQ ID NOs: 2, 4 and 6 or modified sequences thereof.

  本发明的一个目的是提供一种转化体，这种转化体经过改变后可产生次级代谢产物，其中 次级产物的苯环在对位上被含有氮原子的官能团修饰。根据本发明，一种转化体是产生具有苯环骨架的次级代谢产物的生物体的转化体，该次级代谢产物的苯环骨架在对位上未被含有氮原子的官能团取代，所述转化体通过引入参与从络石酸到对氨基苯丙酮酸的生物合成途径的基因进行转化，从而产生具有苯环骨架的次级代谢产物，该次级代谢产物的苯环骨架在对位上被含有氮原子的官能团取代。本发明的另一个目的是提供一种参与从壳斗菜酸到对氨基苯基丙酮酸的生物合成途径的新型基因。根据本发明的新型基因包括编码 SEQ ID NOs: 2、4 和 6 的氨基酸序列或其修饰序列的基因。
• Anti-Inflammatory and Anti-Allergy Extracts from Nettle
  申请人：Alberte Randall S.

  公开号：US20100009927A1

  公开（公告）日：2010-01-14

  The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions.