bis[2-(2-butoxyethoxy)ethyl] (E)-but-2-enedioate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: bis[2-(2-butoxyethoxy)ethyl] (E)-but-2-enedioate
• 化学式: C₂₀H₃₆O₈
• 分子量: 404.5
• InChiKey: NWJSKPQKMSBDIN-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• SKIN EXTERNAL AGENTS AND DRUGS
  申请人：Kanebo Limited

  公开号：EP1249237A1

  公开（公告）日：2002-10-16

  The present invention provides an epidermal permeability barrier function-enhancing agent, an amphiregulin expression inhibitor, an epidermal hyperproliferation inhibitor, a heparin-binding epidermal growth factor-like growth factor (HB-EGF) expression inducing agent, an ameliorating agent for aged skin, an agent to be used together with retinoic acid or a derivative thereof, an agent to prevent dry skin caused by retinoic acid, and a skin external agent composition, which all comprises fumaric acid diester derivatives expressed by the following general formula (1) wherein R1 represents a C1-4 alkylene group; R2 and R3 each represents a linear or branched C1-8 alkyl group; and n is an integer of 2 to 5.

  本发明提供了一种表皮通透性屏障功能增强剂、一种表皮生长素表达抑制剂、一种表皮过度增殖抑制剂、一种肝素结合表皮生长因子样生长因子（HB-EGF）表达诱导剂、一种老化皮肤改善剂，一种与维甲酸或其衍生物一起使用的制剂，一种防止维甲酸引起皮肤干燥的制剂，以及一种皮肤外用制剂组合物，它们都包含由以下通式（1）表示的富马酸二酯衍生物 其中 R1 代表 C1-4 亚烷基；R2 和 R3 分别代表直链或支链 C1-8 烷基；n 为 2 至 5 的整数。
• Skin external agents and drugs
  申请人：——

  公开号：US20030185786A1

  公开（公告）日：2003-10-02

  Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein R 1 represents C 1-4 alkylene; R 2 and R 3 represent each liner or branched C 1-8 alkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.

  皮肤外用剂组合物和药物，其特征在于含有以下通式(1)代表的富马酸二酯衍生物，其中 R 1 代表 C 1-4 亚烷基；R 2 和 R 3 分别代表衬里或支链 C 1-8 烷基；和 n 是 2 至 5 的整数；提供具有高安全性的表皮屏障功能增效剂和皮肤外用制剂组合物，可快速缓解表皮渗透屏障功能失效，并具有使皮肤保持美容健康状态的效果；与加速表皮新陈代谢的 HB-EFG 表达诱导剂、调节表皮过度增殖的两性胰岛素表达抑制剂和防止维甲酸或其衍生物引起皮肤皲裂的维甲酸或其衍生物一起使用的制剂；以及能够改善与衰老相关的皮肤代谢抑制和变薄的皮肤衰老缓解剂。
• Topical cosmetic and pharmaceutical composition comprising specific alkoxylated diester of fumaric acid
  申请人：Kao Corporation

  公开号：EP1249237B1

  公开（公告）日：2007-07-18
• US7037489B2
  申请人：——

  公开号：US7037489B2

  公开（公告）日：2006-05-02