(2R)-2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethenylsulfonylmethyl]anilino]-2-phenylacetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethenylsulfonylmethyl]anilino]-2-phenylacetic acid
• 化学式: C₂₇H₂₉NO₈S
• 分子量: 527.6
• InChiKey: KEVFAHSHSRDVLW-AREMUKBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• TREATMENT OF DRUG-RESISTANT PROLIFERATIVE DISORDERS
  申请人：Temple University - Of The Commonwealth System of Higher Education

  公开号：EP1841420B1

  公开（公告）日：2011-12-07
• Treatment of Drug-Resistant Proliferative Disorders
  申请人：Reddy M. V. Ramana

  公开号：US20090306207A1

  公开（公告）日：2009-12-10

  α,β-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar 1 , Ar 2 , X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competitive kinase inhibitors.
• [EN] PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS<br/>[FR] PROTECTION DE TISSUS ET DE CELLULES DES EFFETS CYTOTOXIQUES D'UN RAYONNEMENT IONISANT PAR DES INHIBITEURS ABL
  申请人：UNIV TEMPLE

  公开号：WO2005044181A2

  公开（公告）日：2005-05-19

  Pre-treatment with one or more compounds of formula (I), as described herein, protects normal cells from the toxic side effects of ionizing radiation. Administration of one or more radioprotective compounds of formula (I) to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of one or more compounds of formula (I) allows for the safe increase the dosage of anticancer radiation. Amelioration of toxicity following inadvertent radiation exposure may also be mitigated with administration of one or more compounds of formula (I).
• [EN] PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS<br/>[FR] LA PROTECTION DE TISSUS ET DE CELLULES CONTRE LES EFFETS CYTOTOXIQUE D'UN RAYONNEMENT IONISANT PAR DES INHIBITEURS ABL
  申请人：UNIV TEMPLE

  公开号：WO2005065074A2

  公开（公告）日：2005-07-21

  Pre-treatment with one or more compounds of formula (I), as described herein, protects normal cells from the toxic side effects of ionizing radiation. Administration of one or more radioprotective compounds of formula I to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of one or more compounds of formula I allows for the safe increase the dosage of anticancer radiation. Amelioration of toxicity following inadvertent radiation exposure may also be mitigated with administration of one or more compounds of formula (I).