N-苯基-1,3-噻唑-2-胺 | 33142-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-苯基-1,3-噻唑-2-胺
• 中文别名: N-苯基-2-氨基噻唑
• 英文名称: N-Phenyl-2-aminothiazole
• 英文别名: Phenyl-[3H-thiazol-(2E)-ylidene]-amine
• CAS: 33142-18-6
• 化学式: C₉H₈N₂S
• mdl: MFCD06124126
• 分子量: 176.24
• InChiKey: OGVGQYZRJXSMGC-UHFFFAOYSA-N

物化性质

• 熔点：
  127-128 °C
• 沸点：
  297.7±23.0 °C(Predicted)
• 密度：
  1.275±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934100090

文献信息

• [DE] INDOL-ODER BENZIMIDAZOLDERIVATE ZUR MODULATION DER I kappa B-KINASE<br/>[EN] INDOLE OR BENZIMIDAZOLE DERIVATIVES FOR MODULATING IkappaB KINASE<br/>[FR] DERIVES D'INDOLE OU DE BENZIMIDAZOLE POUR MODULER L'I kappa B KINASE
  申请人：AVENTIS PHARMA GMBH

  公开号：WO2004022553A1

  公开（公告）日：2004-03-18

  Verbindungen der Formel (I) eignen sich zur Herstellung von Arzneimitteln zur Prophylaxe and Therapie von Erkrankungen, an deren Verlauf eine verstärkte Aktivität von IλB kinease beteiligt ist.

  Formula (I)的连接适用于制备用于预防和治疗与IλB激酶增强活性有关的疾病的药物。
• NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS
  申请人：Nell Peter

  公开号：US20100093728A1

  公开（公告）日：2010-04-15

  The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

  本发明涉及新型取代的2,4′-和3,4′-联吡啶衍生物，涉及它们的制备方法，涉及它们用于治疗和/或预防疾病的用途，以及涉及它们用于制备用于治疗和/或预防疾病的药物，优选用于治疗和/或预防高血压和其他心血管疾病。
• CYCLICALLY SUBSTITUTED 3,5-DICYANO-2-THIOPYRIDINES AND USE THEREOF
  申请人：Nell Peter

  公开号：US20100022544A1

  公开（公告）日：2010-01-28

  The present application relates to novel 4-cycloalkyl- and 4-heterocycloalkyl-3,5-dicyano-2-thio-pyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

  本申请涉及新型的4-环烷基和4-杂环烷基-3,5-二氰基-2-硫代吡啶衍生物，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防高血压和其他心血管疾病。
• Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents
  申请人：Pevarello Paolo

  公开号：US20050004120A1

  公开（公告）日：2005-01-06

  A method of modulating apoptosis or treating diseases associated with protein kinases by administering to a mammal in need thereof of an effective amount of 2-amino-1,3-thiazole derivatives represented by formula (I) or (II): where R, R 1 , R 2 and R 3 are as defined herein, or pharmaceutically acceptable salts thereof.

  通过向需要的哺乳动物投予有效量的由公式(I)或(II)表示的2-氨基-1,3-噻唑衍生物，或其药学上可接受的盐，来调节凋亡或治疗与蛋白激酶相关的疾病的方法：其中R、R1、R2和R3如本文所定义。
• Phenylacetamido-thiazole derivatives, process for the preparation and their use as antitumor agents
  申请人：——

  公开号：US20040235919A1

  公开（公告）日：2004-11-25

  Compounds represented by formula (I), as defined in the description, wherein R is a hydrogen atom or a methyl group and R1 is a group as defined in the specification, or a pharmaceutically acceptable salt thereof, are disclosed; the said compounds are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.

  公式(I)所代表的化合物，如描述中所定义，其中R是氢原子或甲基基团，R1是规范中定义的基团，或其药用盐，均已披露；所述化合物在治疗细胞增殖紊乱疾病（如癌症）方面具有用途，与细胞周期依赖性激酶活性异常有关。