2-[2-[2-[4-(Dibutylamino)phenyl]ethenyl]-1,3-benzothiazol-3-ium-3-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-[2-[4-(Dibutylamino)phenyl]ethenyl]-1,3-benzothiazol-3-ium-3-yl]acetic acid
• 英文别名: 2-[2-[2-[4-(dibutylamino)phenyl]ethenyl]-1,3-benzothiazol-3-ium-3-yl]acetic acid
• 化学式: C25H31N2O2S+
• 分子量: 423.6
• InChiKey: XMVUNIIQQRCJIH-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD FOR PRODUCING ARTIFICIAL RETINA
  申请人：National University Corporation Okayama University

  公开号：EP3127558A1

  公开（公告）日：2017-02-08

  There is provided a method for producing an artificial retina in which an organic dye compound that induces a receptor potential responding to photostimulation is fixed on a polymer sheet substrate, comprising a bonding step of immersing the substrate in a solution containing the organic dye compound to chemically bond the organic dye compound to the substrate; a first washing step of washing with water the substrate to which the organic dye compound has been chemically bonded; and a second washing step of, after the first washing step, washing with an organic solvent the substrate to which the organic dye compound has been chemically bonded. Thus, there can be provided an artificial retina which has excellent mechanical properties such as elongation at break and good biocompatibility, and is capable of inducing a receptor potential responding to photostimulation with high sensitivity.

  本发明提供了一种生产人造视网膜的方法，在该方法中，可诱导对光刺激做出反应的受体电位的有机染料化合物被固定在聚合物片基底上，该方法包括粘合步骤：将基底浸入含有有机染料化合物的溶液中，使有机染料化合物与基底化学粘合；第一清洗步骤，用水清洗有机染料化合物已化学键合的基底；以及 第二清洗步骤，在第一清洗步骤之后，用有机溶剂清洗有机染料化合物已化学键合的基底。这样，就可以提供一种人造视网膜，它具有优异的机械性能，如断裂伸长率和良好的生物相容性，并能以高灵敏度诱导受体电位对光刺激做出反应。
• Method for producing artificial retina
  申请人：NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

  公开号：US10039861B2

  公开（公告）日：2018-08-07

  There is provided a method for producing an artificial retina in which an organic dye compound that induces a receptor potential responding to photostimulation is fixed on a polymer sheet substrate, comprising a bonding step of immersing the substrate in a solution containing the organic dye compound to chemically bond the organic dye compound to the substrate; a first washing step of washing with water the substrate to which the organic dye compound has been chemically bonded; and a second washing step of, after the first washing step, washing with an organic solvent the substrate to which the organic dye compound has been chemically bonded. Thus, there can be provided an artificial retina which has excellent mechanical properties such as elongation at break and good biocompatibility, and is capable of inducing a receptor potential responding to photostimulation with high sensitivity.

  本发明提供了一种生产人造视网膜的方法，在该方法中，可诱导对光刺激做出反应的受体电位的有机染料化合物被固定在聚合物片基底上，该方法包括粘合步骤：将基底浸入含有有机染料化合物的溶液中，使有机染料化合物与基底化学粘合；第一清洗步骤，用水清洗有机染料化合物已化学键合的基底；以及 第二清洗步骤，在第一清洗步骤之后，用有机溶剂清洗有机染料化合物已化学键合的基底。这样，就可以提供一种人造视网膜，它具有优异的机械性能，如断裂伸长率和良好的生物相容性，并能以高灵敏度诱导受体电位对光刺激做出反应。