5-oxo-7,7-bis(p-tolylthio)heptanoic Acid | 1243342-69-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-oxo-7,7-bis(p-tolylthio)heptanoic Acid
• 英文别名: 7,7-bis[(4-methylphenyl)sulfanyl]-5-oxoheptanoic acid
• CAS: 1243342-69-9
• 化学式: C₂₁H₂₄O₃S₂
• 分子量: 388.552
• InChiKey: NRGVEOZQCYZDRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7-(trimethylsilyl)-5-oxohept-6-ynoic acid 在 4-二甲氨基吡啶 sodium tetraborate decahydrate 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 90.0h， 生成 5-oxo-7,7-bis(p-tolylthio)heptanoic Acid
  参考文献：
  名称：

  CONUGATED PROTEINS AND PEPTIDES

  摘要：

  通式（I）的新化合物：其中X代表聚合物；Q代表连接基团；W代表一个电子吸引基团或通过还原电子吸引基团制备的基团；R1和R2各自独立地代表氢原子或C1-4烷基基团；Z1代表通过亲核基团与CR2链接的蛋白质或肽，Z2代表通过亲核基团与CR2链接的分子，或者Z1和Z2一起代表由蛋白质或肽派生出的单个基团，通过两个亲核基团与CR链接。

  公开号：

  US20120014905A1

文献信息

• CONJUGATED PROTEINS AND PEPTIDES
  申请人：POLYTHERICS LIMITED

  公开号：US20150216994A1

  公开（公告）日：2015-08-06

  Novel compounds of the general formula: in which X represents a polymer, Q represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; each of R 1 and R 2 independently represents a hydrogen atom or a C 1-4 alkyl group; and either Z 1 represents a protein or a peptide linked to CR 2 via a nucleophilic moiety, and Z 2 represents a molecule linked to CR 2 via a nucleophilic moiety, or Z 1 and Z 2 together represent a single group derived from a protein or peptide linked to CR 2 via two nucleophilic moieties.

  通用公式的新化合物： 其中，X代表聚合物，Q代表连接基团；W代表电子吸引基团或可通过还原电子吸引基团制备的基团；R1和R2各自独立地代表氢原子或C1-4烷基基团；并且Z1代表通过亲核基团与CR2连接的蛋白质或肽，Z2代表通过亲核基团与CR2连接的分子，或Z1和Z2共同代表由蛋白质或肽通过两个亲核基团连接到CR2的单一基团。
• Conjugated proteins and peptides
  申请人：Godwin Antony Robert

  公开号：US09005598B2

  公开（公告）日：2015-04-14

  Novel compounds of the general formula (I): in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; each of R1 and R2 independently represents a hydrogen atom or a C1-4alkyl group; and either Z1 represents a protein or a peptide linked to CR2 via a nucleophilic moiety, and Z2 represents a molecule linked to CR2 via a nucleophilic moiety, or Z1 and Z2 together represent a single group derived from a protein or peptide linked to CR via two nucleophilic moieties.

  通式（I）的新化合物：其中X代表聚合物；Q代表连接基团；W代表电子吸引基团或通过还原电子吸引基团可制备的基团；R1和R2各自独立地代表氢原子或C1-4烷基基团；并且，Z1代表通过亲核基团与CR2连接的蛋白质或肽，Z2代表通过亲核基团与CR2连接的分子，或者Z1和Z2一起代表从蛋白质或肽中得出的单个基团，该蛋白质或肽通过两个亲核基团与CR连接。
• US9005598B2
  申请人：——

  公开号：US9005598B2

  公开（公告）日：2015-04-14
• US9415115B2
  申请人：——

  公开号：US9415115B2

  公开（公告）日：2016-08-16
• [EN] CONJUGATED PROTEINS AND PEPTIDES<br/>[FR] PROTÉINES ET PEPTIDES CONJUGUÉS
  申请人：POLYTHERICS LTD

  公开号：WO2010100430A1

  公开（公告）日：2010-09-10

  Novel compounds of the general formula (I): in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron- withdrawing moiety; each of R1 and R2 independently represents a hydrogen atom or a C1-4alkyl group; and either Z1 represents a protein or a peptide linked to CR2 via a nucleophilic moiety, and Z2 represents a molecule linked to CR2 via a nucleophilic moiety, or Z1 and Z2 together represent a single group derived from a protein or peptide linked to CR via two nucleophilic moieties.