6-(5-Ethyl-2-methoxyphenyl)-3-methyl-6-oxohexa-2,4-dienoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 6-(5-Ethyl-2-methoxyphenyl)-3-methyl-6-oxohexa-2,4-dienoic acid
• 英文别名: 6-(5-ethyl-2-methoxyphenyl)-3-methyl-6-oxohexa-2,4-dienoic acid
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.31
• InChiKey: KUCNKMGLJCJKEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositios comprising them and processes for the preparation of them
  申请人：Brunet Michel

  公开号：US20060052447A1

  公开（公告）日：2006-03-09

  The invention relates to compounds of the formula I: and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.

  本发明涉及公式I的化合物及其药学上可接受的盐，制备它们的方法和包含它们的制药组合物，特别适用于治疗和预防血脂异常、动脉粥样硬化和糖尿病。
• NOVEL SUBSTITUTED ARYLHEXADIENOIC ACIDS AND ESTERS THEREOF WHICH CAN BE USED FOR THE TREATMENT AND PREVENTION OF DIABETES, DYSLIPIDAEMIA AND ATHEROSCLEROSIS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THE PREPARATION OF THEM
  申请人：Merck Patent GmbH

  公开号：EP1546083B1

  公开（公告）日：2010-08-11
• US7737176B2
  申请人：——

  公开号：US7737176B2

  公开（公告）日：2010-06-15