2-Thiophen-2-ylpentanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Thiophen-2-ylpentanedioic acid
• 英文别名: 2-thiophen-2-ylpentanedioic acid
• 化学式: C₉H₁₀O₄S
• 分子量: 214.24
• InChiKey: QTWPLASYBNDPOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AMPHOTERIC DISSOCIATION ION EXCHANGE MEDIUM, APPLICATION METHOD, AND SEPARATION CAPACITY CALIBRATION METHOD
  申请人：Chongqing Bolanying (BLY) Biotechnology Co., Ltd., China

  公开号：EP3546066A1

  公开（公告）日：2019-10-02

  An amphoteric dissociation ion exchange medium. The surface of the amphoteric dissociation ion exchange medium is an amphoteric dissociation covalent modification layer. When an environmental pH value is lower than an isoelectric point of the amphoteric dissociation covalent modification layer, the surface net charge of the amphoteric dissociation covalent modification layer is positive, so that the amphoteric dissociation covalent modification layer has the property of anion exchanger; when the environmental pH value is higher than isoelectric point of the amphoteric dissociation covalent modification layer, the surface net charge of the amphoteric dissociation covalent modification layer is negative, so that the amphoteric dissociation covalent modification layer has the property of cation exchanger. The separation medium respectively has the property of the anion exchanger and the cation exchanger at the two sides of the isoelectric point, so that by adjusting the pH value of an eluant, the net charges on the surface of the separation medium and a target substance are same, so that a target substance can be released due to electrostatic repulsion, the elution effect is enhanced and subsequent problems due to application of high-concentration inorganic ions are avoided. The novel ion exchange medium has a high separation capacity, a high elution effect on the absorbed ions in a moderate condition, can accurately calibrate a separation capacity, has low non-specific adsorption to hydrophobic small molecules, and has a high regeneration effect in the moderate condition.

  两性解离离子交换介质。两性解离离子交换介质的表面是两性解离共价修饰层。当环境 pH 值低于两性离解共价修饰层的等电点时，两性离解共价修饰层的表面净电荷为正，因此两性离解共价修饰层具有阴离子交换特性；当环境 pH 值高于两性解离共价改性层的等电点时，两性解离共价改性层的表面净电荷为负，使两性解离共价改性层具有阳离子交换特性。分离介质在等电点两侧分别具有阴离子交换剂和阳离子交换剂的性质，因此通过调节洗脱剂的 pH 值，分离介质表面的净电荷与目标物质的净电荷相同，这样目标物质就能因静电排斥而释放出来，洗脱效果增强，避免了后续因应用高浓度无机离子而产生的问题。新型离子交换介质具有高分离能力，在中等条件下对吸收的离子具有高洗脱效果，可准确校准分离能力，对疏水小分子的非特异性吸附低，在中等条件下具有高再生效果。
• Amphoteric dissociation ion exchange medium and uses thereof and method for calibrating separation capacity thereof
  申请人：CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD.

  公开号：US11358136B2

  公开（公告）日：2022-06-14

  An amphoteric dissociation ion exchange separation medium, the surface of which is an amphoteric dissociation covalently-modified layer. When an environmental pH value is lower than the isoelectric point, pIm, of the covalently-modified layer, the type of net charges on the surface of the covalently-modified layer is positive and the separation medium has the properties of an anion exchanger; when the environmental pH value is higher than the pIm, the type of net charges on the covalently-modified layer surface is negative and the separation medium has the properties of a cation exchanger. The separation medium has the properties of an anion exchanger and a cation exchanger at both sides of the pIm, respectively. The pH of an eluent can be adjusted to allow the separation medium surface and the target substance to have the same type of net charges, so that the target substance can be released by electrostatic repulsion.

  两性解离离子交换分离介质，其表面是两性解离共价改性层。当环境 pH 值低于共价改性层的等电点 pIm 时，共价改性层表面的净电荷类型为正电荷，分离介质具有阴离子交换器的特性；当环境 pH 值高于 pIm 时，共价改性层表面的净电荷类型为负电荷，分离介质具有阳离子交换器的特性。分离介质在 pIm 两侧分别具有阴离子交换器和阳离子交换器的特性。可以调节洗脱液的 pH 值，使分离介质表面和目标物质具有相同类型的净电荷，从而通过静电排斥释放目标物质。
• AMPHOTERIC DISSOCIATION ION EXCHANGE MEDIUM, ITS USE, AND SEPARATION CAPACITY CALIBRATION METHOD
  申请人：Chongqing Bolanying (BLY) Biotechnology Co., Ltd., China

  公开号：EP3546066B1

  公开（公告）日：2021-01-20
• AMPHOTERIC DISSOCIATION ION EXCHANGE MEDIUM AND USES THEREOF AND METHOD FOR CALIBRATING SEPARATION CAPACITY THEREOF
  申请人：CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD.

  公开号：US20190291095A1

  公开（公告）日：2019-09-26

  An amphoteric dissociation ion exchange separation medium, the surface of which is an amphoteric dissociation covalently-modified layer. When an environmental pH value is lower than the isoelectric point, pIm, of the covalently-modified layer, the type of net charges on the surface of the covalently-modified layer is positive and the separation medium has the properties of an anion exchanger; when the environmental pH value is higher than the pIm, the type of net charges on the covalently-modified layer surface is negative and the separation medium has the properties of a cation exchanger. The separation medium has the properties of an anion exchanger and a cation exchanger at both sides of the pIm, respectively. The pH of an eluent can be adjusted to allow the separation medium surface and the target substance to have the same type of net charges, so that the target substance can be released by electrostatic repulsion.