5-Acetamido-2-amino-3,3-dimethyl-4,5-bis(sulfanyl)pentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Acetamido-2-amino-3,3-dimethyl-4,5-bis(sulfanyl)pentanoic acid
• 英文别名: 5-acetamido-2-amino-3,3-dimethyl-4,5-bis(sulfanyl)pentanoic acid
• 化学式: C₉H₁₈N₂O₃S₂
• 分子量: 266.4
• InChiKey: QKTDPBRMPBKEKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  94.4
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• MICROPARTICLES AND NANOPARTICLES HAVING NEGATIVE SURFACE CHARGES
  申请人：Phosphorex, Inc.

  公开号：EP3814272A1

  公开（公告）日：2021-05-05
• COBICISTAT FOR USE IN CANCER TREATMENTS
  申请人：Gilead Sciences, Inc.

  公开号：US20180036289A1

  公开（公告）日：2018-02-08

  The disclosure describes methods for and compositions for treatment of patients having cancers expressing CYP3A enzymes by co-administration of cobicistat with an anticancer agent.
• PHARMACEUTICAL COMPOSITION OF SIGLEC-BINDING AGENTS
  申请人：Phosphorex, Inc.

  公开号：US20220142935A1

  公开（公告）日：2022-05-12

  This invention provides a pharmaceutical composition comprising an agent that can bind Siglec receptors on cell surface. This invention also provides the method of preparing said pharmaceutical composition and the use thereof.
• NOVEL DRUG DELIVERY COMPOSITION AND PROCESS FOR BLOOD-BRAIN BARRIER CROSSING
  申请人：Phosphorex, Inc.

  公开号：US20220175690A1

  公开（公告）日：2022-06-09

  This invention provides polymeric nanoparticles presenting non-conjugated BBB-crossing ligands on their surfaces, compositions and methods of use thereof, as well as non-conjugation methods to produce nanoparticles having BBB-crossing agents on their surfaces.
• MICROPARTICLES AND NANOPARTICLES HAVING SULFATE GROUPS ON THE SURFACE
  申请人：Phosphorex, Inc.

  公开号：US20220175959A1

  公开（公告）日：2022-06-09

  This invention provides polymer particles which contain negative charges on the surface of the particle. Preferably, the particles comprise PLGA and sulfate polymer. The invention also provides polymer particle produced by the methods of the invention.