[2-[[4-(2-Azidoethoxy)-3-methoxyphenyl]methylcarbamothioyloxymethyl]-3-(3,4-dimethylphenyl)propyl] 2,2-dimethylpropanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [2-[[4-(2-Azidoethoxy)-3-methoxyphenyl]methylcarbamothioyloxymethyl]-3-(3,4-dimethylphenyl)propyl] 2,2-dimethylpropanoate
• 英文别名: [2-[[4-(2-azidoethoxy)-3-methoxyphenyl]methylcarbamothioyloxymethyl]-3-(3,4-dimethylphenyl)propyl] 2,2-dimethylpropanoate
• 化学式: C28H38N4O5S
• 分子量: 542.7
• InChiKey: HVZBSZDCSDQRFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  38
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Simplified resiniferatoxin analogues as vanilloid receptor agonist showing excellent analgesic activity and the pharmaceutical compositions containing the same
  申请人：——

  公开号：US20040063786A1

  公开（公告）日：2004-04-01

  The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions that have such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for preventing, alleviating or treating pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neutopathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease or urgent urinary incontinence.

  本发明涉及含有树脂毒素药效团的新型植物辣椒素类似物、具有此类类似物的药物组合物以及它们作为植物辣椒素受体激动剂和强效镇痛剂的用途。本发明提供了一种用于预防、缓解或治疗疼痛、急性疼痛、慢性疼痛、神经病理性疼痛、术后疼痛、偏头痛、关节痛、神经病、神经损伤、糖尿病神经病变、神经退行性疾病、神经性皮肤病、中风、膀胱过敏、肠易激综合征、呼吸系统疾病，如哮喘或慢性阻塞性肺病、皮肤、眼睛或粘膜刺激、发热、胃十二指肠溃疡、炎症性肠病、炎症性疾病或紧急性尿失禁的药物组合物。
• US6872748B2
  申请人：——

  公开号：US6872748B2

  公开（公告）日：2005-03-29
• [EN] SIMPLIFIED RESINIFERATOXIN ANALOGUES AS VANILLOID RECEPTOR AGONIST SHOWING EXCELLENT ANALGESIC ACTIVITY AND THE PHARMACEUTICAL CO MPOSITIONS CONTAINING THE SAME<br/>[FR] ANALOGUES SIMPLIFIES DE RESINIFERATOXINE UTILISES EN TANT QU'AGONISTES DES RECEPTEURS VANILLOIDE PRESENTANT UNE EXCELLENTE ACTIVITE ANALGESIQUE, ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES ANALOGUES
  申请人：DIGITAL BIOTECH CO LTD

  公开号：WO2003027064A1

  公开（公告）日：2003-04-03

  The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonistsand potent analgesics.The present invention provides a pharmaceutical composition for preventing, alleviating or treating pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neutopathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease or urgent urinary incontinence.