N-(2-chloroallyl)-3-methoxyaniline | 41292-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(2-chloroallyl)-3-methoxyaniline
• 英文别名: N-(2-Chlorallyl)-m-anisidin；N-(2-chloroprop-2-enyl)-3-methoxyaniline
• CAS: 41292-23-3
• 化学式: C₁₀H₁₂ClNO
• mdl: MFCD12797689
• 分子量: 197.664
• InChiKey: LFNTYBOGSMMSAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-chloroallyl)-3-methoxyaniline 以5%的产率得到
  参考文献：
  名称：

  MCDONALD B. G.; PROCTOR G. R., J. CHEM. SOC. PERKIN TRANS., PART I, , 1975, NO 15, 1446-1450

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-3-碘丙-1-烯 、 间氨基苯甲醚 在 potassium fluoride 作用下， 以 乙腈 为溶剂， 反应 8.0h， 以67%的产率得到N-(2-chloroallyl)-3-methoxyaniline
  参考文献：
  名称：

  Effective Monoallylation of Anilines Catalyzed by Supported KF

  摘要：

  A mild and straightforward monoallylation procedure for different anilines is described using the efficient, inexpensive, noncorrosive, and environmentally friendly reagent KF-Celite. By using only a 1/1.2 stoichiometric ratio of electrophilic reagent to aniline, in very short reaction times, the monoallylated products are obtained in high isolated yields via this procedure, which works very effectively regardless of the electronic nature of the substituent on the ring, although electron withdrawing groups make the reactions go even faster.

  DOI：

  10.1021/ol070890o

文献信息

• Synthesis and characterization of N-substituted polyanilines and polyindoles and their antibacterial activity
  作者：Lyaysan R. Latypova、Gulsum S. Usmanova、Liliya Ya. Vasilova、Vladimir V. Zorin、Akhat G. Mustafin

  DOI：10.1007/s11696-022-02506-4

  日期：2023.1

  A series of new N-substituted poly (β-haloallylaniline)s were synthesized by the chemical oxidation method. Based on these polymers, various functionalized polyindoles of a new type were obtained. All the polymers were characterized by FTIR, UV–vis spectra, SEM and TGA techniques. Moreover, the antimicrobial activity of the samples synthesized was studied as antibacterial agents against Gram-positive

  采用化学氧化法合成了一系列新型N-取代聚(β-卤代烯丙基苯胺)。基于这些聚合物，获得了各种新型官能化聚吲哚。所有聚合物均通过 FTIR、UV-vis 光谱、SEM 和 TGA 技术进行了表征。此外，合成的样品作为抗菌剂对革兰氏阳性菌枯草芽孢杆菌和革兰氏阴性菌金黄色假单胞菌的抗菌活性进行了研究。证实本研究中制备的聚合物样品显示出抗菌活性。
• McDonald,B.G.; Proctor,G.R., Journal of the Chemical Society. Perkin transactions I, 1975, p. 1446 - 1450
  作者：McDonald,B.G.、Proctor,G.R.

  DOI：——

  日期：——
• Effective Monoallylation of Anilines Catalyzed by Supported KF
  作者：Vittorio Pace、Fernando Martínez、María Fernández、Jose V. Sinisterra、Andrés R. Alcántara

  DOI：10.1021/ol070890o

  日期：2007.7.1

  A mild and straightforward monoallylation procedure for different anilines is described using the efficient, inexpensive, noncorrosive, and environmentally friendly reagent KF-Celite. By using only a 1/1.2 stoichiometric ratio of electrophilic reagent to aniline, in very short reaction times, the monoallylated products are obtained in high isolated yields via this procedure, which works very effectively regardless of the electronic nature of the substituent on the ring, although electron withdrawing groups make the reactions go even faster.
• MCDONALD B. G.; PROCTOR G. R., J. CHEM. SOC. PERKIN TRANS., PART I, <JCPK-BH>, 1975, NO 15, 1446-1450
  作者：MCDONALD B. G.、 PROCTOR G. R.

  DOI：——

  日期：——