N-(2-chloroallyl)-4-methoxyaniline | 15332-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(2-chloroallyl)-4-methoxyaniline
• 英文别名: N-(2-chloroprop-2-enyl)-4-methoxyaniline
• CAS: 15332-71-5
• 化学式: C₁₀H₁₂ClNO
• mdl: MFCD12761825
• 分子量: 197.664
• InChiKey: GWQDUKLMLUEJCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-chloroallyl)-4-methoxyaniline 以25%的产率得到
  参考文献：
  名称：

  MCDONALD B. G.; PROCTOR G. R., J. CHEM. SOC. PERKIN TRANS., PART I, , 1975, NO 15, 1446-1450

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-3-碘丙-1-烯 、 甲氧苯胺 在 potassium fluoride 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以79%的产率得到N-(2-chloroallyl)-4-methoxyaniline
  参考文献：
  名称：

  Effective Monoallylation of Anilines Catalyzed by Supported KF

  摘要：

  A mild and straightforward monoallylation procedure for different anilines is described using the efficient, inexpensive, noncorrosive, and environmentally friendly reagent KF-Celite. By using only a 1/1.2 stoichiometric ratio of electrophilic reagent to aniline, in very short reaction times, the monoallylated products are obtained in high isolated yields via this procedure, which works very effectively regardless of the electronic nature of the substituent on the ring, although electron withdrawing groups make the reactions go even faster.

  DOI：

  10.1021/ol070890o

文献信息

• Effective Monoallylation of Anilines Catalyzed by Supported KF
  作者：Vittorio Pace、Fernando Martínez、María Fernández、Jose V. Sinisterra、Andrés R. Alcántara

  DOI：10.1021/ol070890o

  日期：2007.7.1

  A mild and straightforward monoallylation procedure for different anilines is described using the efficient, inexpensive, noncorrosive, and environmentally friendly reagent KF-Celite. By using only a 1/1.2 stoichiometric ratio of electrophilic reagent to aniline, in very short reaction times, the monoallylated products are obtained in high isolated yields via this procedure, which works very effectively regardless of the electronic nature of the substituent on the ring, although electron withdrawing groups make the reactions go even faster.
• MCDONALD B. G.; PROCTOR G. R., J. CHEM. SOC. PERKIN TRANS., PART I, <JCPK-BH>, 1975, NO 15, 1446-1450
  作者：MCDONALD B. G.、 PROCTOR G. R.

  DOI：——

  日期：——