(R)-3-chloro-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-5-methoxy-benzamidine | 1186605-94-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (R)-3-chloro-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-5-methoxy-benzamidine
• 英文别名: (r)-3-Chloro-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-n-hydroxy-5-methoxy-benzamidine；3-chloro-4-[[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-N'-hydroxy-5-methoxybenzenecarboximidamide
• CAS: 1186605-94-6
• 化学式: C₁₄H₁₉ClN₂O₅
• 分子量: 330.768
• InChiKey: SAOSDUATTVISQR-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  95.5
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  rac-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3,5-dimethyl-benzamidine 、 3-氯-4-羟基-5-甲氧基苯甲腈 、 (R)-(-)-甘油醇缩丙酮 生成 (R)-3-chloro-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-5-methoxy-benzamidine
  参考文献：
  名称：

  NOVEL AMINOMETHYL BENZENE DERIVATIVES

  摘要：

  本发明涉及新型氨甲基苯衍生物，其制备和作为药物活性化合物的用途。所述化合物特别作用为免疫调节剂。

  公开号：

  US20110028449A1

文献信息

• [EN] PYRIDIN-2-YL DERIVATIVES AS IMMUNOMODULATING AGENTS<br/>[FR] DÉRIVÉS DE PYRIDIN-2-YLE UTILISÉS COMME AGENTS IMMUNOMODULATEURS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009109872A1

  公开（公告）日：2009-09-11

  The invention relates to pyridine derivatives of Formula (I), wherein A, R1, R2, R3, R4, R5, R6 and R7 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  这项发明涉及公式（I）的吡啶衍生物，其中A、R1、R2、R3、R4、R5、R6和R7如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• [EN] PYRIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE PYRIDINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009109906A1

  公开（公告）日：2009-09-11

  The invention relates to pyridine compounds, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  这项发明涉及吡啶化合物，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• Aminomethyl benzene derivatives
  申请人：Bolli Martin

  公开号：US08410151B2

  公开（公告）日：2013-04-02

  The invention relates to novel aminomethyl benzene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  本发明涉及新型氨甲基苯衍生物，其制备及作为药物活性化合物的用途。这些化合物特别作为免疫调节剂起作用。
• PYRIDIN-2-YL DERIVATIVES AS IMMUNOMODULATING AGENTS
  申请人：Bolli Martin

  公开号：US20100331372A1

  公开（公告）日：2010-12-30

  The invention relates to pyridine derivatives of Formula (I) wherein A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及式（I）的吡啶衍生物，其中A、R1、R2、R3、R4、R5、R6和R7如描述中所述，它们的制备方法以及它们作为药物活性化合物的用途。所述化合物特别作为免疫调节剂。
• PYRIDINE COMPOUNDS
  申请人：Bolli Martin

  公开号：US20110028448A1

  公开（公告）日：2011-02-03

  The invention relates to pyridine compounds, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及吡啶化合物，其制备和用作药物活性化合物。这些化合物特别作为免疫调节剂。