(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[6-[4-[(2S)-2-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-6-(dodecanoylamino)hexanoyl]piperazin-1-yl]-4-oxoquinazolin-3-yl]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-N-[(2S)-3-(1H-indol-3-yl)-1-[[(3S)-2-methyl-4-oxopentan-3-yl]amino]-1-oxopropan-2-yl]butanediamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[6-[4-[(2S)-2-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-6-(dodecanoylamino)hexanoyl]piperazin-1-yl]-4-oxoquinazolin-3-yl]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-N-[(2S)-3-(1H-indol-3-yl)-1-[[(3S)-2-methyl-4-oxopentan-3-yl]amino]-1-oxopropan-2-yl]butanediamide
• 化学式: C₈₈H₁₂₉N₂₁O₁₅
• 分子量: 1721.1
• InChiKey: DANPPRMMIGHTNZ-JZFXQVFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  124
• 可旋转键数：
  54
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  534
• 氢给体数：
  17
• 氢受体数：
  19

文献信息

• Neoropeptide-2-Receptor (Y-2R) Agonists
  申请人：Danho Waleed

  公开号：US20100179093A1

  公开（公告）日：2010-07-15

  Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.