5-Amino-5-oxo-4-(1-oxoisoindolin-2-yl)pentanoic acid | 75179-73-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Amino-5-oxo-4-(1-oxoisoindolin-2-yl)pentanoic acid
• 英文别名: 5-amino-5-oxo-4-(3-oxo-1H-isoindol-2-yl)pentanoic acid
• CAS: 75179-73-6
• 化学式: C₁₃H₁₄N₂O₄
• 分子量: 262.26
• InChiKey: CLIBJHIOJOBIQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED 1-OXO-ISOINDOLINE-5-CARBOXAMIDE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH<br/>[FR] COMPOSÉS DE 1-OXO-ISOINDOLINE-5-CARBOXAMIDE SUBSTITUÉS, COMPOSITIONS DE CEUX-CI, ET PROCÉDÉS DE TRAITEMENT ASSOCIÉS
  申请人：CELGENE CORP

  公开号：WO2020243379A1

  公开（公告）日：2020-12-03

  Provided herein are 1-oxo-isoindoline-5-carboxamide compounds having the following structure of Formula (I), wherein R1, R2, R3, R4 and n are as defined herein, compositions comprising an effective amount of a 1-oxo-isoindoline-5-carboxamide compound, and methods for treating or preventing disorders.

  本文提供了具有以下结构的1-氧代异吲哚啉-5-甲酰胺化合物的结构（I），其中R1、R2、R3、R4和n的定义如本文所述，包括有效量的1-氧代异吲哚啉-5-甲酰胺化合物的组合物，以及用于治疗或预防疾病的方法。
• Compositions for inhibition of anglogenesis
  申请人：The Children's Medical Center Corporation

  公开号：EP1920773A1

  公开（公告）日：2008-05-14

  The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Additionally, anti-inflammatory drugs, such as steroids and NSAIDs can inhibit angiogenesis dependent diseases either alone or in combination with thalidomide and related compounds. Importantly, these compounds can be administered orally.

  本发明包括一组能有效抑制血管生成的化合物。更具体地说，沙利度胺和各种相关化合物，如沙利度胺前体、类似物、代谢物和水解产物，已被证明可抑制血管生成和治疗血管生成导致的疾病状态。此外，抗炎药物，如类固醇和非甾体抗炎药物，可单独或与沙利度胺及相关化合物联合使用，抑制血管生成相关疾病。重要的是，这些化合物可以口服给药。
• Methods for the treatment of atherosclerosis, using substituted phenethylsulfones
  申请人：Zeldis B. Jerome

  公开号：US20080096952A1

  公开（公告）日：2008-04-24

  Methods and compositions for the prevention and treatment of all forms of atherosclerosis are described. Administration of compounds such as thalidomide, its analogs, hydrolysis products, metabolites, derivatives and precursors as well as additional compounds capable of inhibiting tumor necrosis factor α (TNF-α) are used in the invention. Also disclosed is the coating of prosthetic devices, such as stents, with the compounds of the invention for the prevention and/or treatment of restenosis.
• SUBSTITUTED 1-OXO-ISOINDOLINE-5-CARBOXAMIDE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Celgene Corporation

  公开号：US20200377512A1

  公开（公告）日：2020-12-03

  Provided herein are 1-oxo-isoindoline-5-carboxamide compounds having the following structure: wherein R 1 , R 2 , R 3 , R 4 and n are as defined herein, compositions comprising an effective amount of a 1-oxo-isoindoline-5-carboxamide compound, and methods for treating or preventing disorders.
• US7723361B2
  申请人：——

  公开号：US7723361B2

  公开（公告）日：2010-05-25