(2S,4R)-4-(4-methylphenyl)sulfonyloxypyrrolidine-1,2-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4R)-4-(4-methylphenyl)sulfonyloxypyrrolidine-1,2-dicarboxylic acid
• 化学式: C₁₃H₁₅NO₇S
• 分子量: 329.33
• InChiKey: LBEQBTXAQXRZEG-KOLCDFICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] PROLINE-BASED NEUROPEPTIDE FF RECEPTOR MODULATORS<br/>[FR] MODULATEURS DU RÉCEPTEUR FF DE NEUROPEPTIDE À BASE DE PROLINE
  申请人：RES TRIANGLE INST

  公开号：WO2018152134A1

  公开（公告）日：2018-08-23

  Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF 1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

  基于脯氨酸支架的神经肽FF受体调节剂提供了纳摩尔级别的NPFF受体效力，并对NPFF 1受体具有拮抗选择性。提供了调节神经肽FF受体功能的方法、化合物和组合物，用于影响受神经肽FF受体影响的疾病或疾病的药理疗法。
• MASP-2 INHIBITORS AND METHODS OF USE
  申请人：Omeros Corporation

  公开号：US20210171461A1

  公开（公告）日：2021-06-10

  The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

  本公开提供了具有MASP-2抑制活性的化合物，这些化合物的组合物，以及制备和使用这些化合物的方法。
• IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS
  申请人：Deutsches Krebsforschungszentrum

  公开号：EP3992191A1

  公开（公告）日：2022-05-04

  The present invention relates to imidazo[4,5-c]quinoline compounds and to their use in the inhibition, regulation and/or modulation of signal transduction by ATM kinase and, in particular, for the treatment of ATM mediated diseases, especially cancer.

  本发明涉及咪唑[4,5-c]喹啉化合物及其在ATM激酶信号转导的抑制、调节和/或调节中的使用，特别是用于治疗ATM介导的疾病，尤其是癌症。
• SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS
  申请人：Genentech, Inc.

  公开号：US20160221945A1

  公开（公告）日：2016-08-04

  The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

  本发明涉及公式I或II的化合物及其盐。此外，本发明还涉及制造和使用公式I或II化合物的方法，以及包含这些化合物的制药组合物。这些化合物可能有用于治疗由TRPA1介导的疾病和病况，如疼痛。
• [EN] INHIBITORS OF AMINO ACID TRANSPORT<br/>[FR] INHIBITEURS DU TRANSPORT D'ACIDES AMINÉS
  申请人：ICAHN SCHOOL MED MOUNT SINAI

  公开号：WO2022087630A1

  公开（公告）日：2022-04-28

  Disclosed herein are compounds and compositions of formula (I) that are inhibitors of amino acid transport, specifically alanine serine cysteine transporter 2 (ASCT2): These compounds are useful as therapeutic agents for treating various cancers. Methods for inhibiting an ASCT2 transporter are also disclosed. Certain compounds are selective for an ASCT transporter.

  本文公开了式（I）的化合物和组合物，它们是氨基酸转运抑制剂，特别是丙氨酸/丝氨酸/半胱氨酸转运蛋白2（ASCT2）的抑制剂：这些化合物可用作治疗各种癌症的治疗剂。还公开了抑制ASCT2转运蛋白的方法。某些化合物对ASCT转运蛋白具有选择性。