4-(2-hydroxy-4-benzyloxyphenyl)-6-(4-fluorophenyl)-2-aminopyrimidine | 1415657-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(2-hydroxy-4-benzyloxyphenyl)-6-(4-fluorophenyl)-2-aminopyrimidine
• 英文别名: 2-[2-Amino-6-(4-fluorophenyl)pyrimidin-4-yl]-5-phenylmethoxyphenol；2-[2-amino-6-(4-fluorophenyl)pyrimidin-4-yl]-5-phenylmethoxyphenol
• CAS: 1415657-58-7
• 化学式: C₂₃H₁₈FN₃O₂
• 分子量: 387.413
• InChiKey: GSONTHSQXPTUGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  81.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 硫酸 、 溶剂黄146 、 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 4-(2-hydroxy-4-benzyloxyphenyl)-6-(4-fluorophenyl)-2-aminopyrimidine
  参考文献：
  名称：

  Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents

  摘要：

  A novel series of 4,6-diaryl-2-aminopyrimidines 8a-o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61-9.53 mu g/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.

  DOI：

  10.1007/s00044-012-0328-z

文献信息

• Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents
  作者：Rajani Giridhar、Riyaj S. Tamboli、Dhaval G. Prajapati、Sanket Soni、Sarita Gupta、M. R. Yadav

  DOI：10.1007/s00044-012-0328-z

  日期：2013.7

  A novel series of 4,6-diaryl-2-aminopyrimidines 8a-o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61-9.53 mu g/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.