2,4-dimethyl-3-ethylphenol | 62126-74-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dimethyl-3-ethylphenol
• 英文别名: 3-ethyl-2,4-dimethyl-phenol；4-Hydroxy-1.3-dimethyl-2-aethyl-benzol；3-Aethyl-2,4-dimethyl-phenol；3-Ethyl-2,4-dimethylphenol
• CAS: 62126-74-3
• 化学式: C₁₀H₁₄O
• 分子量: 150.221
• InChiKey: JNJMMVLVPLHOKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4-dimethyl-3-ethylphenol 、 异氰酸苯酯 生成 phenyl-carbamic acid-(3-ethyl-2,4-dimethyl-phenyl ester)
  参考文献：
  名称：

  E FFECTS OF P REHOSPITAL N ITROGLYCERIN ON H EMODYNAMICS AND C HEST P AIN I NTENSITY

  摘要：

  Objective: To assess the effects of prehospital nitroglycerin (NTG) on vital signs and chest pain intensity. Methods: A retrospective review of advanced life support (ALS) run sheets was performed in a suburban volunteer emergency medical services (EMS) system receiving 8,000 annual ALS calls. All consecutive patients who were administered NTG by EMS were included. Standardized forms were used to collect data on patient demographics, history, and physical exam. Patients assessed their chest pain (CP) before and after NTG on a verbal numeric scale of 0-10 from least to most severe. The presence of syncope, dysrhythmias, or profound hypotension [loss of peripheral pulses, a systolic blood pressure (SBP) of <90 mm Hg after NTG, or a drop of >100 mm Hg in BP] was noted. Results. One thousand six hundred sixty-two patients received NTG over 18 months, their mean age was 66 years, and 48% were female. Indications for NTG included CP (83%), dyspnea (45%), and congestive heart failure (20%). After NTG administration, the CP score decreased from 6.9 to 4.4 (mean difference = 2.6; 95% CI = 2.4 to 2.8). The CP completely resolved in 10% of the patients. Mean decreases in SBPs and diastolic BPs were 11.8 mm Hg (95% CI = 10.7 to 13.0) and 4.0 mm Hg (95% CI = 2.9 to 5.1). The mean pulse rate increased by 2.7 beats/min (95% CI = 0.6 to 4.9). There were 12 patients with adverse events [0.7% (95% CI = 0.4% to 1.3%)], including profound bradycardia and hypotension (1), transient drop in SBP of 100 mm Hg responding to fluids (6), post-NTG SBP <90 mm Hg (4), and syncope (1). There were no deaths in the prehospital setting. Conclusions: Use of prehospital NTG appears safe. While NTG reduces CP, most patients have residual pain.

  DOI：

  10.1080/10903120090940967
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 磷酸 作用下， 生成 2,4-dimethyl-3-ethylphenol
  参考文献：
  名称：

  v. Auwers; Mauss, Justus Liebigs Annalen der Chemie, 1928, vol. 460, p. 266

  摘要：

  DOI：

文献信息

• PROCESS FOR THE MANUFACTURE OF POLYPHENOLS
  申请人：Fetsko Stephen W.

  公开号：US20090137848A1

  公开（公告）日：2009-05-28

  An improved process for the manufacture of a polyphenol compound such as bisphenol-A by introducing into a reaction zone a phenolic compound reactant, a carbonyl compound reactant, and a catalyst promoter comprising bismethylthiopropane added to the reaction system in certain specific locations, and reacting the ingredients within the reaction zone in the presence of an acid catalyst.

  一种改进的制造多酚类化合物（如双酚-A）的工艺，通过将酚类反应物、羰基化合物反应物和催化剂促进剂（包括添加到反应系统中的双甲基硫代丙烷）引入反应区域的特定位置，并在酸性催化剂的存在下在反应区域内反应这些成分。
• [EN] CATALYST SYSTEM AND PROCESS FOR PRODUCING BISPHENOL-A<br/>[FR] SYSTÈME CATALYSEUR ET PROCESSUS DE PRODUCTION DU BISPHÉNOL-A
  申请人：BADGER LICENSING LLC

  公开号：WO2018200278A1

  公开（公告）日：2018-11-01

  A catalyst system useful in the production of bisphenol-A comprises (a) an acidic heterogeneous catalyst; (b) a first catalyst promoter comprising at least one organic sulfur- containing compound; and (c) a second catalyst promoter different from the first catalyst promoter and comprising at least one organic Brønsted acidic ionic compound..

  在生产双酚A时有用的催化剂系统包括(a)酸性杂化催化剂；(b)第一催化剂促进剂，包括至少一种有机硫化合物；(c)第二催化剂促进剂不同于第一催化剂促进剂，包括至少一种有机Brønsted酸性离子化合物。
• Process for the production of a bisphenol
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0469689A2

  公开（公告）日：1992-02-05

  In a process for the preparation of a bisphenol by condensation of a phenolic compound and a carbonyl compound in the presence of an acidic ion exchange resin catalyst, strong acids that leach from the acidic ion exchange resin catalyst into the reaction effluent are scavenged by a carbon adsorbent. The acid scavenging improves the product quality and yield by reducing acid catalyzed cracking of bisphenols during purification and finishing steps.

  在一种通过在酸性离子交换树脂催化剂存在下缩合酚类化合物和羰基化合物制备双酚的工艺中，从酸性离子交换树脂催化剂中渗入反应流出物的强酸会被碳吸附剂清除。酸清除可减少纯化和精制步骤中酸催化双酚的裂解，从而提高产品质量和产量。
• Process for purifying a bisphenol
  申请人：DOW DEUTSCHLAND INC.

  公开号：EP0675097A1

  公开（公告）日：1995-10-04

  A process for the purification of a crude bisphenol comprises the following steps: (1) preparing a mixture comprising from 35 to 70 percent of a crude bisphenol and from 65 to 30 percent of water, by the total weight of bisphenol and water, without the addition of a substantial amount of an organic solvent or an alkaline compound, at a pressure above atmospheric and a temperature above 100°C, (2) crystallizing bisphenol at a pressure below atmospheric, (3) separating crystalline bisphenol from the mother liquor, (4) dividing at least a portion of the mother liquor into a bisphenol-rich oil phase and a water-rich phase, (5) preparing a mixture comprising at least a portion of the bisphenol-rich oil phase, water and optionally an additional amount of crude bisphenol at a pressure above atmospheric and a temperature above 100°C, (6) cooling the mixture and crystallizing bisphenol; and (7) separating crystalline bisphenol from the mother liquor.

  一种提纯粗双酚的工艺包括以下步骤： (1) 在压力高于大气压和温度高于 100℃的条件下，制备一种混合物，按双酚和水的总重量计，该混合物包括 35%至 70%的粗双酚和 65%至 30%的水，且不添加大量有机溶剂或碱性化合物、 (2) 在低于大气压的压力下使双酚结晶、 (3) 从母液中分离出结晶双酚、 (4) 将母液的至少一部分分为富含双酚的油相和富含双酚的水相、 (5) 在压力高于大气压和温度高于 100°C 的条件下，制备一种混合物，其中至少包含一部分富含双酚的油相、水和可选的额外数量的粗双酚、 (6) 冷却混合物并使双酚结晶；以及 (7) 从母液中分离出结晶双酚。
• Process for preparing an adduct of a bisphenol with a phenolic compound
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0720976A1

  公开（公告）日：1996-07-10

  A process for preparing an adduct of a bisphenol with a phenolic compound comprises the following steps: a) reacting a carbonyl compound with a stoichiometric excess of a phenolic compound in the presence of an acidic cation exchange resin as a catalyst, to produce a product mixture containing a bisphenol, unreacted phenolic compound, unreacted carbonyl compound and water, and b) crystallizing an adduct of the bisphenol with the phenolic compound from the product mixture in a crystallization device in the presence of water and acetone. The product mixture obtained in step a) is not subjected to a distillation step before the product mixture enters the crystallization device.

  一种制备双酚与酚类化合物加合物的工艺包括以下步骤： a) 在酸性阳离子交换树脂作为催化剂的存在下，使羰基化合物与按化学计量过量的酚类化合物反应，生成含有双酚、未反应的酚类化合物、未反应的羰基化合物和水的产品混合物，以及 b) 在有水和丙酮存在的情况下，在结晶装置中从产品混合物中结晶出双酚与酚类化合物的加合物。 在步骤 a) 中得到的产品混合物在进入结晶装置之前不经过蒸馏步骤。