N1-hydroxy-N1,N2-diphenylbenzamidine | 53170-30-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N1-hydroxy-N1,N2-diphenylbenzamidine
• 英文别名: N-Hydroxy-N.N'-diphenyl-benzamidin
• CAS: 53170-30-2
• 化学式: C₁₉H₁₆N₂O
• 分子量: 288.349
• InChiKey: LSBWGXUVQQIGMF-FMQUCBEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.66
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.83
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N1-hydroxy-N1,N2-diphenylbenzamidine 、 对甲苯磺酰氯 以10%的产率得到
  参考文献：
  名称：

  BINDING, N.;HEESING, A., CHEM. BER., 1983, 116, N 5, 1822-1833

  摘要：

  DOI：
• 作为产物：
  描述：

  (Z)-N-phenylbenzimidoyl chloride 、 苯基羟胺 以50%的产率得到
  参考文献：
  名称：

  MOLLIN, J.;KASPARKOVA, V., ACTA UNIV. PALACK. OLOMUC., FAC. RERUM. NATUR. CHEM., 1982, 73, N 21, 23-+

  摘要：

  DOI：

文献信息

• [EN] HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF<br/>[FR] DERIVES D'HYDROXYLAMINE UTILISES POUR AMELIORER LA PRODUCTION DE CHAPERONS MOLECULAIRES ET LEUR PREPARATION
  申请人：BIOREX KUTATÓ ÉS FEJLESZTÓ RT.

  公开号：WO1997016439A1

  公开（公告）日：1997-05-09

  (EN) A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, a hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which a hydroxylamine derivative is administered is a eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.(FR) Procédé visant à accroître l'expression d'un chaperon moléculaire par une cellule et/ou à intensifier l'activité de celui-ci dans les cellules. Le procédé consiste à traiter une cellule qui est exposée à une tension physiologique induisant l'expression d'un chaperon moléculaire par la cellule avec une quantité efficace d'un certain dérivé d'hydroxylamine afin d'augmenter la tension. Selon une autre variante, un dérivé d'hydroxylamine peut être administré à une cellule avant d'être exposé à une tension physiologique induisant l'expression d'un chaperon moléculaire par la cellule. De préférence, la cellule dans laquelle est administré le dérivé d'hydroxylamine est une cellule eucaryote. Le dérivé d'hydroxylamine correspond aux formules (I) et (II). L'invention se rapporte également à des nouveaux dérivés d'hydroxylamine relevant des formules (I) et (II), ainsi qu'à des compositions pharmaceutiques et/ou cosmétiques comprenant ces composés.

  本发明提供了一种增加细胞分子伴侣表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理压力的细胞，以增加压力。或者，在细胞暴露于诱导细胞分子伴侣表达的生理压力之前，可以向细胞中注入羟胺衍生物。最好注入羟胺衍生物的细胞是真核细胞。该羟胺衍生物对应于式（I）或（II）。本发明还提供了在式（I）和（II）范围内的新的羟胺衍生物，以及包含这些化合物的药物和/或化妆品组合物。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。
• HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF
  申请人：BIOREX KUTATO ES FEJLESZTÖ RT.

  公开号：EP0801649A2

  公开（公告）日：1997-10-22
• Non-toxic corrosion-protection rinses and seals based on rare earth elements
  申请人：——

  公开号：US20040016910A1

  公开（公告）日：2004-01-29

  Rinsing or sealing solutions comprising a rare earth element and a valence stabilizer for barrier films. The treated films contain a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, praseodymium, terbium, or combinations thereof, and at least one rare earth element is in the tetravalent oxidation state. The rinsing or sealing solution may also contain an optional preparative or solubility control agent. The oxidized rare earth element is present in the coating in a “sparingly soluble” form. The valence stabilizers can be either inorganic or organic in nature. A number of rare earth/valence stabilizer combinations that match the performance of conventional hexavalent chromium systems are presented.