N-[2-[2-(icosa-5,8,11,14-tetraenoylamino)ethyldisulfanyl]ethyl]icosa-5,8,11,14-tetraenamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-[2-[2-(icosa-5,8,11,14-tetraenoylamino)ethyldisulfanyl]ethyl]icosa-5,8,11,14-tetraenamide
• 化学式: C₄₄H₇₂N₂O₂S₂
• 分子量: 725.2
• InChiKey: JYAHNJUEZOKHHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  50
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Novel cytotoxic compounds and their Use
  申请人：——

  公开号：US20030171338A1

  公开（公告）日：2003-09-11

  Novel amides of polyunsaturated fatty acids with cysteamine-S-phosphate have been synthesized. Combinations of the all-trans-retinoic acid and/or amides of the 13-cis-retinoic acid with O-phospho-L-tyrosine, and N-docosahex-aenoyl-cysteamine-S-phosphate, N-eicosapentaenoyl-cysteamine-S-phosphate, N-arachidonoyl-cysteamine-S-phosphate, N-&agr;-linolenoyl-cysteamine-S-phosphate, and N-&ggr;-linolenoyl-cysteamine-S-phosphate and their analogues N-docosahex-aenoyl-O-phospho-2-aminoethanol, N-eicosapentaenoyl-O-phospho-2-aminoethanol, N-arachidonoyl-O-phospho-2-aminoethanol, N-&agr;-linolenoyl-O-phospho-2-aminoethanol, N-&ggr;-linolenoyl-O-phospho-2-aminoethanol in different compositions exhibit a marked cell-growth inhibiting effect and display anti-tumour activity.

  已经合成了多不饱和脂肪酸的新型酰胺，其中含有半胱氨酸-S-磷酸盐。全反式视黄酸和/或13-顺-视黄酸酰胺与O-磷酸-L-酪氨酸、N-二十二碳六烯酰半胱氨酸-S-磷酸盐、N-二十碳五烯酰半胱氨酸-S-磷酸盐、N-花生四烯酰半胱氨酸-S-磷酸盐、N-α-亚麻酸半胱氨酸-S-磷酸盐和N-γ-亚麻酸半胱氨酸-S-磷酸盐及其类似物N-二十二碳六烯酰-O-磷酸-2-氨基乙醇、N-二十碳五烯酰-O-磷酸-2-氨基乙醇、N-花生四烯酰-O-磷酸-2-氨基乙醇、N-α-亚麻酸-O-磷酸-2-氨基乙醇、N-γ-亚麻酸-O-磷酸-2-氨基乙醇以不同的组合，表现出明显的抑制细胞生长的效果，并显示出抗肿瘤活性。
• NOVEL CYTOTOXIC COMPOUNDS AND THEIR USE
  申请人：Ardenia Investments Ltd.

  公开号：EP1299400A1

  公开（公告）日：2003-04-09
• US6699851B2
  申请人：——

  公开号：US6699851B2

  公开（公告）日：2004-03-02
• [EN] NOVEL CYTOTOXIC COMPOUNDS AND THEIR USE<br/>[FR] NOUVEAUX COMPOSES CYTOTOXIQUES ET LEUR UTILISATION
  申请人：ARDENIA INVESTMENTS LTD

  公开号：WO2002004467A1

  公开（公告）日：2002-01-17

  Novel amides of polyunsaturated fatty acids with cysteamine-S-phosphate have been synthesized. Combinations of the all-trans-retinoic acid and/or amides of the 13-cis-retinoic acid with 0-phospho-L-tyrosine, and N-docosahexaenoyl-cysteamine-S-phosphate, N-eicosapentaenoyl-cysteamine-S-phosphate, N-arachidonoyl-cysteamine-S-phosphate, N-α-linolenoyl-cysteamine-S-phosphate, and N-η-linolenoyl-cysteamine-S-phosphate and their analogues N-docosahexaenoyl-O-phospho-2-aminoethanol, N-eicosapentaenoyl-O-phospho-2-aminoethanol, N-arachidonoyl-O-phospho-2-aminoethanol, N-α-linolenoyl-O-phospho-2-aminoethanol, N-η-linolenoyl-O-phospho-2-aminoethanol in different compositions exhibit a marked cell-growth inhibiting effect and display anti-tumour activity.