Ethyl 2-pentadeca-3,6,9,12-tetraenoxybutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl 2-pentadeca-3,6,9,12-tetraenoxybutanoate
• 英文别名: ethyl 2-pentadeca-3,6,9,12-tetraenoxybutanoate
• 化学式: C₂₁H₃₄O₃
• 分子量: 334.5
• InChiKey: QCVIPYRFVMTKQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Novel lipid compounds
  申请人：Pronova BioPharma Norge AS

  公开号：EP2248798A1

  公开（公告）日：2010-11-10

  The present invention relates to lipid compounds of the general formula (I): wherein R1 is selected from a C10-C22 alkyl, a C10-C22 alkenyl having 1-6 double bonds, and a C10-C22 alkynyl having 1-6 triple bonds;R2 and R3 are the same or different and may be selected from a group of different substituents; and X represents a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.

  本发明涉及通式（I）的脂质化合物：其中R1选择自C10-C22烷基，具有1-6个双键的C10-C22烯基和具有1-6个三键的C10-C22炔基；R2和R3相同或不同，可以选择不同的取代基组成；X代表羧酸或其衍生物，如羧酸酯，羧酸酐或羧酰胺；或其药学上可接受的盐，溶剂化物，该盐的溶剂化物或其前药。本发明还涉及包含这些化合物的制药组合物和脂质组合物，以及将这些化合物用作药物或用于治疗，特别是用于治疗与心血管，代谢和炎症相关的疾病。