2,4,6-tri-O-methylgalactitol | 20227-15-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,4,6-tri-O-methylgalactitol
• 英文别名: 2,4,6-tri-O-methyl-d-galactitol；(2S,3R,4S,5R)-2,4,6-trimethoxyhexane-1,3,5-triol
• CAS: 20227-15-0
• 化学式: C₉H₂₀O₆
• 分子量: 224.254
• InChiKey: SCUVHLFJAYEWFC-XAVMHZPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.4
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (3R,4S,5S,6R)-3,5-Dimethoxy-6-methoxymethyl-4-((2R,3R,4S,5S,6R)-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ol 生成 2,3,4,6-tetra-O-methyldulcitol 、 2,4,6-tri-O-methylgalactitol
  参考文献：
  名称：

  Structural investigation of Klebsiella serotype K46 poly-saccharide

  摘要：

  The structure of the capsular polysaccharide from Klebsiella type K46 has been investigated by using the techniques of methylation analysis, periodate oxidation, and partial hydrolysis. The anomeric linkages were determined by 1H- and 13C-n.m.r. spectroscopy of the polysaccharide and of derived poly- and oligo-saccharides obtained through degradative procedures. 1H-N.m.r. spectroscopy of the polysaccharide in D2O showed clearly a ratio of one (1-carboxyethylidene) group (CH3, delta 1.47) to six anomeric protons (delta 4.62--5.29). The polysaccharide was shown to consist of the following hexasaccharide repeating unit, which is unique in this series in having a (1-carboxyethylidene) acetal group on a lateral, but nonterminal, sugar residue. (Formula: see text).

  DOI：

  10.1016/s0008-6215(00)85903-0

文献信息

• The capsular polysaccharide of klebsiella serotype K60; a novel, structural pattern
  作者：Guy G.S. Dutton、Jose Di Fabio

  DOI：10.1016/s0008-6215(00)85197-6

  日期：1980.12

  Non-linear capsular polysaccharides of Klebsiella bacteria usually have a single side-chain per repeating unit, or, less commonly, two side-chains attached to the same unit. The capsular polysaccharide from Klebsiella serotype K60 is unique in having three side-chains in the heptasaccharide repeating-unit shown. The structure, including the configuration of the glycosidic linkages, was established

  克雷伯氏菌细菌的非线性荚膜多糖通常每个重复单元有一条侧链，或者较不常见的是，两条重复链附着在同一单元上。来自克雷伯氏菌血清型K60的荚膜多糖的独特之处在于在所示的七糖重复单元中具有三个侧链。包括糖苷键构型在内的结构主要是通过表征寡糖来确定的，该寡糖是通过原始水解，荚膜多糖和聚合物的部分水解而得到的，该水解是通过侧链的Smith降解去除的（式，参见文本）。
• Novel helicobacter pylori-binding substances and use thereof
  申请人：——

  公开号：US20040086514A1

  公开（公告）日：2004-05-06

  Helicobacter pylori -binding substances comprising Gal&bgr;3GlcNAc or Gal&bgr;3GalNAc are described, as well as use thereof in pharmaceutical compositions and food-stuff, and methods for treatment of conditions due to the presence of Helicobacter pylori . Also use of said substance for the identification of bacterial adhesions, for the production of a vaccine against Helicobacter pylori , for diagnosis of Helicobacter pylori infections, for typing of Helicobacter pylori , for identification of Helicobacter pylori binding substances and for inhibition of the binding of Helicobacter pylori is described.

  幽门螺杆菌 -描述了由 Gal&bgr;3GlcNAc 或 Gal&bgr;3GalNAc 组成的幽门螺旋杆菌结合物质及其在药物组合物和食品中的用途，以及治疗因幽门螺旋杆菌存在而引起的疾病的方法。 幽门螺旋杆菌 .所述物质还可用于鉴定细菌粘附、生产针对幽门螺旋杆菌的疫苗，以及用于治疗因幽门螺旋杆菌存在而引起的疾病的方法。 幽门螺旋杆菌 诊断 幽门螺旋杆菌 幽门螺旋杆菌的分型 幽门螺旋杆菌的分型 鉴定 幽门螺旋杆菌 结合物质和抑制幽门螺旋杆菌的结合 幽门螺旋杆菌 描述。
• Structural investigation of Klebsiella serotype K46 poly-saccharide
  作者：Koichi Okutani、Guy G.S. Dutton

  DOI：10.1016/s0008-6215(00)85903-0

  日期：1980.11

  The structure of the capsular polysaccharide from Klebsiella type K46 has been investigated by using the techniques of methylation analysis, periodate oxidation, and partial hydrolysis. The anomeric linkages were determined by 1H- and 13C-n.m.r. spectroscopy of the polysaccharide and of derived poly- and oligo-saccharides obtained through degradative procedures. 1H-N.m.r. spectroscopy of the polysaccharide in D2O showed clearly a ratio of one (1-carboxyethylidene) group (CH3, delta 1.47) to six anomeric protons (delta 4.62--5.29). The polysaccharide was shown to consist of the following hexasaccharide repeating unit, which is unique in this series in having a (1-carboxyethylidene) acetal group on a lateral, but nonterminal, sugar residue. (Formula: see text).