4-ethoxy-2-methoxy-1-[(E)-2-[(E)-2-phenylethenyl]sulfonylethenyl]benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-ethoxy-2-methoxy-1-[(E)-2-[(E)-2-phenylethenyl]sulfonylethenyl]benzene
• 化学式: C₁₉H₂₀O₄S
• 分子量: 344.4
• InChiKey: JFCFJZFATQUBQO-PHEQNACWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Method for protecting cells and tissues from ionizing radiation toxicity with alpha, beta unsaturated aryl sulfones
  申请人：——

  公开号：US20030060505A1

  公开（公告）日：2003-03-27

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective &agr;,&bgr; unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of &agr;,&bgr; unsaturated arylsulfone.

  预处理使用α，β不饱和芳基磺酮可以保护正常细胞免受电离辐射的毒副作用。在抗癌放疗之前向患者给予放射性保护α，β不饱和芳基磺酮化合物可以减少辐射对正常细胞的细胞毒性副作用。α，β不饱和芳基磺酮的辐射保护效果可以让临床医生安全地增加抗癌放射剂量。在某些情况下，无意中接触辐射后毒性的缓解可以通过给予α，β不饱和芳基磺酮来缓解。
• Formulations of radioprotective alpha, beta unsaturated aryl sulfones
  申请人：Onconova Therapeutics, Inc.

  公开号：EP2769719A1

  公开（公告）日：2014-08-27

  Solution and suspension formulations are provided for administration prior to or after exposure to ionizing radiation for reducing toxic effects of the radiation in a subject which comprises an effective amount of at least one radioprotective α, β unsaturated aryl sulfone wherein the composition has a pH within the range of about 8 to about 9.

  本发明提供了溶液和悬浮液制剂，用于在电离辐射照射前或照射后给药，以减少辐射对受试者的毒性影响，该制剂包含有效量的至少一种辐射保护性 α、β 不饱和芳基砜，其中组合物的 pH 值在约 8 到约 9 的范围内。
• EP1370253A4
  申请人：——

  公开号：EP1370253A4

  公开（公告）日：2005-08-17
• USE OF ALPHA, BETA UNSATURATED ARYL SULFONES FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY
  申请人：Temple University - of the Commonwealth System of Higher Education

  公开号：EP1370253B8

  公开（公告）日：2008-11-26
• METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH $g(a), $g(b) UNSATURATED ARYL SULFONES
  申请人：Temple University of the CommonwealthSystem of Higher Education

  公开号：EP1370253A2

  公开（公告）日：2003-12-17