4-Octadec-9-enoyl-6-oxotricos-14-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Octadec-9-enoyl-6-oxotricos-14-enoic acid
• 英文别名: 4-octadec-9-enoyl-6-oxotricos-14-enoic acid
• 化学式: C₄₁H₇₄O₄
• 分子量: 631.0
• InChiKey: BKIRWXHYWLBNCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.4
• 重原子数：
  45
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
  申请人：Panzner Steffen

  公开号：US20080089932A1

  公开（公告）日：2008-04-17

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种由混合脂质组成的两性脂质体，所述混合物包括阳离子型两性分子、阴离子型两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子型和阴离子型两性分子可被电荷化，所述阳离子型和阴离子型两性分子的相应量被选择为在第一个较低的pH下具有过量的正电荷的阳离子型两性分子，在第二个较高的pH下具有过量的负电荷的阴离子型两性分子，且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述的阳离子型和阴离子型两性分子适合在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• Lipids and lipid assemblies comprising transfection enhancer elements
  申请人：Panzner Steffen

  公开号：US20080306153A1

  公开（公告）日：2008-12-11

  Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety-pH sensitive hydrophilic moiety  (II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I): Lipid moiety-[Hydrophobic moiety-pH sensitive hydrophilic moiety]  (I)

  本发明揭示了包含转染增强元素（TEE）的脂质组装体，例如脂质体，这些TEE通过离子相互作用与脂质组装体形成复合物，或者包含此类TEE的脂质。这些TEE的公式为：疏水基团-pH敏感亲水基团（II）。每个TEE的pH敏感亲水基团是一种弱酸，其pka在2到6之间，或者是包含酸性基团和pKa在3到8之间的弱碱性基团的双电离结构的组合。包含一个或多个此类TEE的脂质的公式为（I）：脂质基团-[疏水基团-pH敏感亲水基团]（I）。该发明旨在提高脂质组装体的融合性。
• Amphoteric Liposomes, A Method Of Formulating An Amphoteric Liposome And A Method Of Loading An Amphoteric Liposome
  申请人：Panzner Steffen

  公开号：US20120135065A1

  公开（公告）日：2012-05-31

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种两性脂质体，由混合脂质组成，所述混合物包括阳离子两性分子、阴离子两性分子和可选的一个或多个中性两性分子，其中至少一种阳离子和阴离子两性分子是可带电的，并且所述阳离子和阴离子两性分子的相应量被选择为在第一个较低的pH值下存在过量的带正电荷的阳离子两性分子，在第二个较高的pH值下存在过量的带负电荷的阴离子两性分子，并且所述混合物具有介于第一个和第二个pH值之间的等电点；其特征在于所述带正电荷的阳离子和带负电荷的阴离子两性分子被适应在所述等电点处彼此形成脂质盐。还公开了预测在给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• AMPHOTERIC LIPOSOME FORMULATIONS
  申请人：Marina Biotech, Inc.

  公开号：US20160151282A1

  公开（公告）日：2016-06-02

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  由混合脂质组成的两性脂质体，所述混合物包括阳离子两性分子、阴离子两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子和阴离子两性分子可被带电，并且所述阳离子和阴离子两性分子的相应量被选择为在第一个较低pH下存在过量的带正电的阳离子两性分子，在第二个较高pH下存在过量的带负电的阴离子两性分子，并且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述带正电的阳离子和带负电的阴离子两性分子被适应在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• Emulation of lipoprotein structures
  申请人：Marina Biotech, Inc.

  公开号：EP2277508A1

  公开（公告）日：2011-01-26

  The invention concerns lipid assemblies, liposomes having an outer surface comprising a mixture of anionic and cationic moieties; wherein at least a portion of the cationic moieties are guanido groups, and their use for serum resistant transfection of cells.

  本发明涉及脂质组合物，脂质体的外表面包含阴离子和阳离子的混合物；其中阳离子至少有一部分是鸟苷酸基团，以及它们在细胞抗血清转染中的用途。