8-Hydroxy octadecamonoenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-Hydroxy octadecamonoenoic acid
• 英文别名: 8-hydroxyoctadec-2-enoic acid
• 化学式: C₁₈H₃₄O₃
• 分子量: 298.5
• InChiKey: WKIJWZLZWWJXLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PRODUCTION OF NON-NATIVE MONOUNSATURATED FATTY ACIDS IN BACTERIA
  申请人：Genomatica, Inc.

  公开号：EP3844269A1

  公开（公告）日：2021-07-07
• [EN] USE OF FATTY ACID COMPOUNDS FOR LOWERING BLOOD GLUCOSE LEVELS<br/>[FR] EMPLOI D'ACIDES GRAS DANS LA DIMINUTION DE LA GLYCÉMIE SANGUINE
  申请人：BRIDGE BIORES PLC

  公开号：WO2011089265A1

  公开（公告）日：2011-07-28

  Use of a compound of the general formula (I), COOH-CHR-(CH2)m-CH=CH-(CH2)n-CH3 (I), wherein R can be any group with a molecular weight from 14 to 200 Da, m and n are independently selected from an integer of 3 to 10, and the double bond is in cis or trans configuration or a mixture thereof, or a pharmaceutically acceptable salt, ester or glyceride thereof, for preparing a pharmaceutical composition for lowering blood glucose.
• [EN] PRODUCTION OF NON-NATIVE MONOUNSATURATED FATTY ACIDS IN BACTERIA<br/>[FR] PRODUCTION D'ACIDES GRAS MONO-INSATURÉS NON NATIFS DANS DES BACTÉRIES
  申请人：GENOMATICA INC

  公开号：WO2020047088A1

  公开（公告）日：2020-03-05

  The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides viable bacterial cells which comprise heterologous dual 3-hydroxy-acyl-ACP dehydratase/isomerases, etc. The disclosure further provides monounsaturated fatty acid derivative molecules produced by the viable bacterial cells which are non-native to the bacterial cells. The disclosure further provides methods for the preparation and production of non-native monounsaturated fatty acid derivative molecules such as e.g., an ω3-monounsaturated fatty acid derivative, an ω5-monounsaturated fatty acid derivative, an ω9-monounsaturated fatty acid derivative, an ω11-monounsaturated fatty acid fatty acid derivative, etc.