(Z)-2-acetyl-3-amino-N-cyclohexylbut-2-enamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-2-acetyl-3-amino-N-cyclohexylbut-2-enamide
• 化学式: C₁₂H₂₀N₂O₂
• 分子量: 224.3
• InChiKey: JTXNNXKDYXTABV-FLIBITNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS
  申请人：The University of Manchester

  公开号：US20180215772A1

  公开（公告）日：2018-08-02

  Inhibitor compounds are disclosed. The compounds are effective in the treatment of diseases or conditions in which interleukin 1 β activity is implicated. Methods of synthesis of the compounds, as well as pharmaceutical compositions comprising the compounds are also disclosed.