Aminoethylmethacrylamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Aminoethylmethacrylamide
• 英文别名: 5-amino-2-methylpent-2-enamide
• 化学式: C₆H₁₂N₂O
• 分子量: 128.17
• InChiKey: AJQXZWKKWGNGPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] FORCE-RESPONSIVE POLYMERSOMES AND NANOREACTORS; PROCESSES UTILIZING THE SAME<br/>[FR] POLYMERSOMES ET NANORÉACTEURS SENSIBLES À LA FORCE; PROCÉDÉS LES UTILISANT
  申请人：ADOLPHE MERKLE INSTITUTE UNIV OF FRIBOURG

  公开号：WO2019034597A1

  公开（公告）日：2019-02-21

  The mechanically induced melting properties of DNA were employed to achieve force labile membranes is described. Nucleobase pairs were used as mechanophores. Adenine and thymine functionalized complementary amphiphilic block copolymers were self-assembled into polymersomes. The nucleobases formed hydrogen bonds which were disrupted upon force stimulation. The exposure of the disconnected nucleobases to the hydrophobic matrix of the membranes lead to a change of permeability which permitted the exchange of water-soluble molecules throughout the polymer matrix. Moreover, the encapsulation of horseradish peroxidase enabled the reaction of luminol with hydrogen peroxide to yield a luminescence producing species similar to the marine bioluminescence. Moreover, the same nano-reactors were employed to catalyze the formation of a polyacrylamide gel when force was applied. Insights into the change of permeability of supramolecular networks upon force are provided. These systems are useful for drug delivery, as nanoreactors and for the selective release of curing agents for 3D printing, or fragrances.

  DNA的机械诱导熔化特性被用来实现易受力破裂的膜。核碱基对被用作机械感受器。腺嘌呤和胸腺嘧啶功能化的互补两性分块共聚物自组装成聚合体囊。核碱基形成氢键，在受力刺激下被破坏。断开的核碱基暴露在膜的疏水基质中，导致渗透性的改变，从而允许水溶性分子在聚合物基质中交换。此外，封装辣根过氧化物酶使得辣根酰胺与过氧化氢反应产生类似海洋生物发光的发光物种。此外，当施加力时，相同的纳米反应器被用来催化聚丙烯酰胺凝胶的形成。提供了关于受力下超分子网络渗透性变化的见解。这些系统可用于药物传递、纳米反应器以及用于3D打印的固化剂或香料的选择性释放。
• Degradable nanoparticles
  申请人：Reddy Ramachandra G.

  公开号：US20050196343A1

  公开（公告）日：2005-09-08

  The present invention relates to polymeric nanoparticles, particularly useful in drug and agent delivery, as well as for imaging and diagnosis. The polymeric nanoparticles of the present invention comprise cross-linkers that, when degraded, leave simple linear polymeric molecules that can be excreted by the body. The present invention also relates to methods of producing the polymeric nanoparticles of the present invention, and methods of using them in drug and agent delivery, as well as imaging and diagnosis.

  本发明涉及聚合物纳米颗粒，特别适用于药物和试剂的输送，以及用于成像和诊断。本发明的聚合物纳米颗粒包括交联剂，当被降解时，会留下简单的线性聚合物分子，可以被人体排泄。本发明还涉及制备本发明的聚合物纳米颗粒的方法，以及在药物和试剂输送、成像和诊断中使用它们的方法。
• Hydroxylamine esters as polymerization initiators
  申请人：——

  公开号：US20030216494A1

  公开（公告）日：2003-11-20

  The invention relates to novel cyclic and open-chain hydroxylamine esters and polymerizable compositions comprising these hydroxylamine esters and an ethylenically unsaturated monomer or oligomer. The invention also relates to use as polymerization initiators and to the use of known hydroxylamine esters selected from the group consisting of HALS compounds and the novel hydroxylamine esters for the controlled degradation of polypropylene and for achieving a controlled increase in the molecular weight of polyethylene.

  该发明涉及新型环状和开链羟胺酯以及包括这些羟胺酯和乙烯基不饱和单体或寡聚物的可聚合组合物。该发明还涉及用作聚合引发剂以及用于控制聚丙烯降解和实现聚乙烯分子量控制增加的已知羟胺酯，所述羟胺酯来自HALS化合物和新颖羟胺酯的组合。
• Phosphoryl choline coating compositions
  申请人：Glauser Thierry

  公开号：US20050208093A1

  公开（公告）日：2005-09-22

  A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

  提供了一种包含磷脂基团和生物相容聚合物骨架的聚合物，一种包含该聚合物和可选生物活性剂的组合物，以及一种可植入装置，如包括覆盖有包含该聚合物和可选生物活性剂的涂层的DES，以及使用该装置治疗人类疾病的方法。
• [EN] GLYCOPOLYMER, METHOD OF PREPARATION THEREOF, USE THEREOF AS MEDICAMENT<br/>[FR] GLYCOPOLYMÈRE, SON PROCÉDÉ DE PRÉPARATION, SON UTILISATION EN TANT QUE MÉDICAMENT
  申请人：USTAV MAKROMOLEKULARNI CHEMIE AV CR V V I

  公开号：WO2021047699A1

  公开（公告）日：2021-03-18

  The invention relates to multivalent glycopolymers based on HPMA polymers (copolymers or homopolymers) with carbohydrate structures containing a terminal monosaccharide in the galacto-configuration, which are effective as galectin inhibitors. These glycopolymers can be used as drugs for the therapy and prevention of oncological diseases associated with overproduction of galectins, especially of human galectin-3 (Gal-3).

  该发明涉及基于HPMA聚合物（共聚物或同聚物）的多价糖聚合物，其含有以半乳糖构型为终端的碳水化合物结构，可作为半乳糖凝集素抑制剂。这些糖聚合物可用作治疗和预防与过度产生凝集素有关的肿瘤性疾病的药物，特别是人类凝集素-3（Gal-3）。