Methyl 2-(2,4-dioxopyrimidin-1-yl)-2-hydroxyacetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-(2,4-dioxopyrimidin-1-yl)-2-hydroxyacetate
• 英文别名: methyl 2-(2,4-dioxopyrimidin-1-yl)-2-hydroxyacetate
• 化学式: C₇H₈N₂O₅
• 分子量: 200.15
• InChiKey: UYJQWUMWORXZNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] CYSTINE CATIONIC LIPIDS<br/>[FR] LIPIDES CATIONIQUES DE CYSTINE
  申请人：TRANSLATE BIO INC

  公开号：WO2020214946A1

  公开（公告）日：2020-10-22

  The present invention provides, in part cystine cationic lipid compounds of formula A, and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

  本发明部分提供了公式A的半胱氨酸阳离子脂质化合物及其子公式：或其药用可接受盐。本文提供的化合物可用于传递和表达mRNA和编码蛋白质，例如作为脂质体传递载体的组成部分，并因此可用于治疗各种疾病、紊乱和病况，如与一个或多个蛋白质缺乏相关的疾病。
• Method for the immobilization of biomolecules
  申请人：Boehringer Ingelheim Vetmedica GmbH

  公开号：US10962534B2

  公开（公告）日：2021-03-30

  The invention relates to a method for the immobilization of biomolecules containing at least one sulfhydryl group, which method comprises contacting a modified metal surface with the biomolecule irradiating the resulting surface with UV radiation in the presence of a photo-initiator, wherein said metal surface is modified with a cross-linker compound comprising a terminal thiol or dithiol group covalently linked to the metal surface, a spacer group, which at the other terminal end is carrying an isolated double or triple bond.

  本发明涉及一种固定含有至少一个巯基的生物大分子的方法，该方法包括将改性金属表面与生物大分子接触，在有光引发剂存在的情况下，用紫外线辐射照射所得表面，其中所述金属表面用交联剂化合物改性，交联剂化合物包括与金属表面共价连接的末端硫醇或二硫醇基团、间隔基团，间隔基团的另一端带有一个孤立的双键或三键。
• CYSTINE CATIONIC LIPIDS
  申请人：Translate Bio, Inc.

  公开号：EP3956303A1

  公开（公告）日：2022-02-23
• THIOESTER CATIONIC LIPIDS
  申请人：Translate Bio, Inc.

  公开号：EP3959195A1

  公开（公告）日：2022-03-02
• [EN] THIOESTER CATIONIC LIPIDS<br/>[FR] LIPIDES CATIONIQUES DE THIOESTER
  申请人：TRANSLATE BIO INC

  公开号：WO2020219427A1

  公开（公告）日：2020-10-29

  The present invention provides, in part, thioester cationic lipid compounds of formula A, and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.