tert-butyl (R)-(1-hydroxy-2-methyl-3-phenylpropan-2-yl)carbamate | 868286-68-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (R)-(1-hydroxy-2-methyl-3-phenylpropan-2-yl)carbamate
• 英文别名: N-Boc-(R)-2-amino-2-methyl-3-phenylpropan-1-ol；tert-butyl ((1R)-1-benzyl-2-hydroxy-1-methylethyl)carbamate；tert-butyl (1-benzyl-2R-hydroxy-1-methylethyl)carbamate；tert-butyl((1R)-1-benzyl-2-hydroxy-1-methylethyl)carbamate；tert-butyl N-[(2R)-1-hydroxy-2-methyl-3-phenylpropan-2-yl]carbamate
• CAS: 868286-68-4
• 化学式: C₁₅H₂₃NO₃
• 分子量: 265.353
• InChiKey: WQPLCPRUYWQWHO-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl (R)-(1-hydroxy-2-methyl-3-phenylpropan-2-yl)carbamate 在 盐酸 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 26.17h， 生成
  参考文献：
  名称：

  介绍非外消旋 β-叔-β-氨基醇，合成氮丙啶、哌嗪和吗啉支架的构件。

  摘要：

  报道了一种制备具有四取代C-立体中心的对映纯 β-叔氨基醇的方法，以及将它们转化为选定的药用特权杂环系统（吗啉、氮丙啶、哌嗪）的方法。这些化合物是通过氨基甲酸烯丙酯的对映特异性σ向重排作为关键步骤获得的。后者由相应的 β,β'-二烷基取代的非外消旋烯丙醇制备。此外，还报道了通过对映选择性 1,2-烯酮还原、酶动力学拆分或手性炔丙醇功能化合成这种高度取代的烯丙醇，并讨论了每种方法的范围和局限性。

  DOI：

  10.1039/d0ob01315c
• 作为产物：
  描述：

  α-甲基-D-苯丙氨酸 在 sodium tetrahydroborate 、 碘 作用下， 以 四氢呋喃 为溶剂， 反应 64.5h， 生成 tert-butyl (R)-(1-hydroxy-2-methyl-3-phenylpropan-2-yl)carbamate
  参考文献：
  名称：

  [EN] 2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  [FR] COMPOSES DERIVES DE PYRIDYLE SUBSTITUES AUX POSITIONS 2, 4, 6 UTILES COMME INHIBITEURS DE LA BETA-SECRETASE DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER

  摘要：

  本发明涉及2,4,6-取代吡啶衍生物化合物，这些化合物是β-分泌酶的抑制剂，可用于治疗涉及β-分泌酶的疾病，如阿尔茨海默病。该发明还涉及包含这些化合物的药物组合物以及在治疗涉及β-分泌酶的疾病中使用这些化合物和组合物。

  公开号：

  WO2005103043A1

文献信息

• [EN] 1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] DERIVES DE PHENYLE 1,3,5-SUBSTITUES UTILES COMME INHIBITEURS DE LA BETA-SECRETASE POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2005103020A1

  公开（公告）日：2005-11-03

  The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及1,3,5-苯基取代衍生物化合物，这些化合物是β-分泌酶的抑制剂，可用于治疗β-分泌酶参与的疾病，例如阿尔茨海默病。该发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在治疗β-分泌酶参与疾病中的用途。
• [EN] 2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] COMPOSES DERIVES DE PYRIDYLE SUBSTITUES AUX POSITIONS 2, 4, 6 UTILES COMME INHIBITEURS DE LA BETA-SECRETASE DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2005103043A1

  公开（公告）日：2005-11-03

  The present invention is directed to 2, 4, 6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer’s disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及2,4,6-取代吡啶衍生物化合物，这些化合物是β-分泌酶的抑制剂，可用于治疗涉及β-分泌酶的疾病，如阿尔茨海默病。该发明还涉及包含这些化合物的药物组合物以及在治疗涉及β-分泌酶的疾病中使用这些化合物和组合物。
• A Protocol for Direct Stereospecific Amination of Primary, Secondary, and Tertiary Alkylboronic Esters
  作者：James Morken、Emma Edelstein、Andrea Grote、Maximilian Palkowitz

  DOI：10.1055/s-0037-1610172

  日期：2018.8

  The direct, stereospecific amination of alkylboronic and borinic esters can be conducted by treatment of the organoboron compound with methoxyamine and potassium tert-butoxide. In addition to being stereospecific, this process also enables the direct amination of tertiary boronic esters in an efficient fashion.

  烷基硼酸酯和硼酸酯的直接立体有择胺化可以通过用甲氧基胺和叔丁醇钾处理有机硼化合物来进行。除了立体有择性之外，该过程还能够以有效的方式直接胺化叔硼酸酯。
• 1,3,5-Substituted Phenyl Derivative Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
  申请人：Barrow C. James

  公开号：US20070244119A1

  公开（公告）日：2007-10-18

  The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及一类1,3,5-苯基取代衍生物化合物，它们是β-分泌酶酶的抑制剂，可用于治疗β-分泌酶酶参与的疾病，如阿尔茨海默病。本发明还涉及包含这些化合物的制药组合物，以及这些化合物和组合物在治疗β-分泌酶酶参与的疾病中的用途。
• 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
  申请人：Merck, Sharp & Dohme, Inc.

  公开号：US07847100B2

  公开（公告）日：2010-12-07

  The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及1,3,5-苯基取代衍生物化合物，其是β-分泌酶酶的抑制剂，并且在治疗β-分泌酶酶参与的疾病中，例如阿尔茨海默病，具有用途。该发明还涉及包含这些化合物的制药组合物，以及在治疗β-分泌酶酶参与的疾病中使用这些化合物和组合物的方法。