3-[4-(Benzyloxycarbonylamino) butyl]-morpholine-2,5-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[4-(Benzyloxycarbonylamino) butyl]-morpholine-2,5-dione
• 英文别名: benzyl N-[4-(2,5-dioxomorpholin-3-yl)butyl]carbamate
• 化学式: C₁₆H₂₀N₂O₅
• 分子量: 320.34
• InChiKey: OEOAIHDRJXRRFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  L-丙交酯 、 3-[4-(Benzyloxycarbonylamino) butyl]-morpholine-2,5-dione 、 、 以 氯仿 为溶剂， 反应 72.0h， 生成 glycolic acid Nepsilon-benzyloxycarbonyl-L-lysine L-lactic acid
  参考文献：
  名称：

  RGD POLYPEPTIDE GRAFTED POLY (GLYCOLIC ACID-L-LYSINE-L-LACTIC ACID) / BETA TRICALCIUM PHOSPHATE COMPOSITE MATERIAL AND PREPARATION METHOD THEREOF

  摘要：

  一种RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸）/β-磷酸三钙复合材料，由β-磷酸三钙颗粒和RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸）组成，质量比为1:10-1:100，其中β-磷酸三钙颗粒均匀分散在RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸）基质中。制备方法包括聚合乙二醇-赖氨酸-乳酸与GRGDY短肽（甘氨酸-精氨酸-甘氨酸-天冬氨酸-酪氨酸序列）以获得RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸），然后将RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸）与β-磷酸三钙颗粒混合制备而成。该复合材料具有良好的生物相容性、细胞亲和性、生物降解性和机械行为，并可避免组织的无菌性坏死，可用作修复神经组织和骨组织的神经导管或多孔骨支架。

  公开号：

  US20080319114A1

文献信息

• RGD POLYPEPTIDE GRAFTED POLY (GLYCOLIC ACID-L-LYSINE-L-LACTIC ACID) / BETA TRICALCIUM PHOSPHATE COMPOSITE MATERIAL AND PREPARATION METHOD THEREOF
  申请人：Li Shipu

  公开号：US20080319114A1

  公开（公告）日：2008-12-25

  An RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid)/β-tricalcium phosphate composite material is composed of β-tricalcium phosphate particles and RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) with mass ratio of 1:10-1:100, in which the β-tricalcium phosphate particles are uniformly dispersed in the RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) matrix. The preparation method includes that poly (glycolic acid-L-lysine-L-lactic acid) is polymerized with GRGDY short peptide (glycin-arginine-glycin-aspartic acid-tyrosine sequence) to obtain RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid), and then RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) is compounded with β-tricalcium phosphate particles. The composite material exhibits favorable biocompatibility, cellular affinity, biodegradability and mechanical behavior, and can avoid aseptic necrosis of tissues, which may be used as nerve guide or porous bone scaffold for repairing nerve tissue and bone tissue.

  一种RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸）/β-磷酸三钙复合材料，由β-磷酸三钙颗粒和RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸）组成，质量比为1:10-1:100，其中β-磷酸三钙颗粒均匀分散在RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸）基质中。制备方法包括聚合乙二醇-赖氨酸-乳酸与GRGDY短肽（甘氨酸-精氨酸-甘氨酸-天冬氨酸-酪氨酸序列）以获得RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸），然后将RGD多肽接枝的聚（乙二醇-赖氨酸-乳酸）与β-磷酸三钙颗粒混合制备而成。该复合材料具有良好的生物相容性、细胞亲和性、生物降解性和机械行为，并可避免组织的无菌性坏死，可用作修复神经组织和骨组织的神经导管或多孔骨支架。
• RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) / β tricalcium phosphate composite material and preparation method thereof
  申请人：Wuhan University of Technology

  公开号：US07989532B2

  公开（公告）日：2011-08-02

  An RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid)/β-tricalcium phosphate composite material is composed of β-tricalcium phosphate particles and RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) with mass ratio of 1:10-1:100, in which the β-tricalcium phosphate particles are uniformly dispersed in the RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) matrix. The preparation method includes that poly (glycolic acid-L-lysine-L-lactic acid) is polymerized with GRGDY short peptide (glycin-arginine-glycin-aspartic acid-tyrosine sequence) to obtain RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid), and then RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) is compounded with β-tricalcium phosphate particles. The composite material exhibits favorable biocompatibility, cellular affinity, biodegradability and mechanical behavior, and can avoid aseptic necrosis of tissues, which may be used as nerve guide or porous bone scaffold for repairing nerve tissue and bone tissue.

  一种RGD多肽嫁接的聚（乙二醇酸-L-赖氨酸-L-乳酸酸）/β-三钙磷酸复合材料由β-三钙磷酸颗粒和RGD多肽嫁接的聚（乙二醇酸-L-赖氨酸-L-乳酸酸）组成，质量比为1：10-1：100，其中β-三钙磷酸颗粒均匀分散在RGD多肽嫁接的聚（乙二醇酸-L-赖氨酸-L-乳酸酸）基质中。制备方法包括聚合乙二醇酸-L-赖氨酸-L-乳酸酸与GRGDY短肽（甘氨酸-精氨酸-甘氨酸-天冬氨酸-酪氨酸序列）以获得RGD多肽嫁接的聚（乙二醇酸-L-赖氨酸-L-乳酸酸），然后将RGD多肽嫁接的聚（乙二醇酸-L-赖氨酸-L-乳酸酸）与β-三钙磷酸颗粒混合。该复合材料具有良好的生物相容性、细胞亲和性、生物可降解性和机械性能，并且可以避免组织的无菌性坏死，可用于修复神经组织和骨组织的神经导管或多孔骨支架。