N，N-二乙基-3-硝基苯乙胺 | 932405-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N，N-二乙基-3-硝基苯乙胺
• 英文名称: N,N-diethyl-2-(3-nitrophenyl)ethanamine
• 英文别名: N,N-Diethyl-3-nitro-benzeneethanamine
• CAS: 932405-32-8
• 化学式: C₁₂H₁₈N₂O₂
• 分子量: 222.287
• InChiKey: MGOKLRJHSRUNBC-UHFFFAOYSA-N

物化性质

• 沸点：
  330.2±25.0 °C(Predicted)
• 密度：
  1.071±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N，N-二乙基-3-硝基苯乙胺 在 5%-palladium/activated carbon 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以100%的产率得到3-(2-(二乙基氨基)乙基)苯胺
  参考文献：
  名称：

  [EN] DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  [FR] COMPOSES ET COMPOSITIONS CONTENANT DE LA DIARYLAMINE, ET UTILISATION EN TANT QUE MODULATEURS DE RECEPTEURS DE C-KIT

  摘要：

  公开号：

  WO2007038669A3
• 作为产物：
  描述：

  3-nitrophenylethyl methanesulfonate 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以75%的产率得到N，N-二乙基-3-硝基苯乙胺
  参考文献：
  名称：

  [EN] DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  [FR] COMPOSES ET COMPOSITIONS CONTENANT DE LA DIARYLAMINE, ET UTILISATION EN TANT QUE MODULATEURS DE RECEPTEURS DE C-KIT

  摘要：

  公开号：

  WO2007038669A3

文献信息

• DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  申请人：Molteni Valentina

  公开号：US20090012094A1

  公开（公告）日：2009-01-08

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文介绍了一种包含二芳胺结构特征的化合物。还介绍了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的制药组合物和药物。本文还介绍了使用这种化合物、制药组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors
  申请人：Molteni Valentina

  公开号：US20070149538A1

  公开（公告）日：2007-06-28

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文描述了包含二芳胺结构特征的化合物。还描述了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的药物组合物和药物。本文还描述了使用这种化合物、药物组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• Synthesis and biological evaluation of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents
  作者：Li Wang、Fenyan Yang、Xiaochun Yang、Xianghong Guan、Chunqi Hu、Tao Liu、Qiaojun He、Bo Yang、Yongzhou Hu

  DOI：10.1016/j.ejmech.2010.11.016

  日期：2011.1

  A series of new 4 beta-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4 beta position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route. (C) 2010 Elsevier Masson SAS. All rights reserved.
• US7563894B2
  申请人：——

  公开号：US7563894B2

  公开（公告）日：2009-07-21
• US7514447B2
  申请人：——

  公开号：US7514447B2

  公开（公告）日：2009-04-07