(1R)-1-(4-ethoxyphenyl)-2-methoxyethanamine hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (1R)-1-(4-ethoxyphenyl)-2-methoxyethanamine hydrochloride
• 英文别名: (1R)-1-(4-ethoxyphenyl)-2-methoxyethan-1-amine hydrochloride；(1R)-1-(4-ethoxyphenyl)-2-methoxyethanamine;hydrochloride
• 化学式: C₁₁H₁₇NO₂*ClH
• mdl: MFCD28246324
• 分子量: 231.722
• InChiKey: BYTFSJMXEAEUSZ-MERQFXBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.31
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  44.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1R)-1-(4-ethoxyphenyl)-2-methoxyethanamine hydrochloride 、 cis-5-fluoro-2H-spiro[1-benzofuran-3,1'-cyclopropane]-2'-carboxylic acid 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 生成 cis-5-fluoro-N-[(1R)-1-(4-ethoxyphenyl)-2-methoxyethyl]-2H-spiro[1-benzofuran-3,1'-cyclopropane]-2-carboxamide
  参考文献：
  名称：

  [EN] ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  [FR] MODULATEURS ALLOSTÉRIQUES DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE

  摘要：

  The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.

  公开号：

  WO2023049058A1
• 作为产物：
  描述：

  tert-butyl [(1R)-1-(4-ethoxyphenyl)-2-hydroxyethyl]carbamate 在 盐酸 、 silver(l) oxide 作用下， 以 1,4-二氧六环 、 乙腈 为溶剂， 反应 64.0h， 生成 (1R)-1-(4-ethoxyphenyl)-2-methoxyethanamine hydrochloride
  参考文献：
  名称：

  [EN] ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  [FR] MODULATEURS ALLOSTÉRIQUES DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE

  摘要：

  The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.

  公开号：

  WO2023049058A1

文献信息

• New positive allosteric modulators of nicotinic acetylcholine receptor
  申请人：H. LUNDBECK A/S

  公开号：US20150315130A1

  公开（公告）日：2015-11-05

  The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

  本发明涉及在治疗中有用的化合物，包括含有该化合物的组合物，以及通过给予该化合物治疗疾病的方法。所提到的化合物是尼古丁乙酰胆碱α7受体的正向变构调节剂（PAMs）。