2-[3-[[4-[6-[5-[(4S)-4-aminopentyl]-3-chloro-2,4-difluorophenyl]-2-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl]phenyl]methylamino]propyl]guanidine | 1416241-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[3-[[4-[6-[5-[(4S)-4-aminopentyl]-3-chloro-2,4-difluorophenyl]-2-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl]phenyl]methylamino]propyl]guanidine
• CAS: 1416241-04-7
• 化学式: C₂₈H₃₃ClF₂N₈O
• 分子量: 571.073
• InChiKey: ACUYVYYCRMRFIT-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  147
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Antimicrobial Compounds and Methods of Making and Using the Same
  申请人：MELINTA THERAPEUTICS, INC.

  公开号：US20160220568A1

  公开（公告）日：2016-08-04

  Methods and compounds for treating, preventing, reducing the risk of and/or delaying the onset of a microbial infection in a subject are disclosed herein, wherein the microbial infection is caused by one or more microorganisms (e.g., one or more bacteria) which can be used as a biological weapon, such as Bacillus anthracis, Franciscella tularensis, Yersinia pestis, Burkholderia mallei, and Burkholderia pseudomallei. Also disclosed are pharmaceutical compositions or kits for treating, preventing, reducing the risk of and/or delaying the onset of a microbial infection.
• US9937183B2
  申请人：——

  公开号：US9937183B2

  公开（公告）日：2018-04-10