2-Amino-5,7-dimethyl-thiazolo<4,5-d>pyrimidin | 2672-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Amino-5,7-dimethyl-thiazolo<4,5-d>pyrimidin
• 英文别名: 5,7-dimethyl-thiazolo[4,5-d]pyrimidin-2-ylamine；5,7-Dimethyl-[1,3]thiazolo[4,5-d]pyrimidin-2-amine
• CAS: 2672-00-6
• 化学式: C₇H₈N₄S
• 分子量: 180.233
• InChiKey: HOZDLLUETOGZBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(2,6-二甲基嘧啶-4-基)硫脲 在 溴 作用下， 以 氯仿 为溶剂， 生成 2-Amino-5,7-dimethyl-thiazolo<4,5-d>pyrimidin
  参考文献：
  名称：

  Barnikow,G.; Boedeker,J., Zeitschrift für Chemie, 1965, vol. 5, p. 62

  摘要：

  DOI：

文献信息

• New Piperazine Compound and Use Thereof as a HCV Polymerase Inhibitor
  申请人：Abe Hiroyuki

  公开号：US20080081818A1

  公开（公告）日：2008-04-03

  The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof and an anti-HCV agent and an HCV polymerase inhibitor containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

  本发明涉及一种由以下式[I]表示的化合物，其中每个符号如规范中定义，或其药学上可接受的盐，或其溶剂化合物，以及含有该化合物的抗HCV剂和HCV聚合酶抑制剂。本发明的化合物基于HCV聚合酶抑制活性显示出抗HCV活性，并且可用作预防或治疗丙型肝炎的药剂。
• POLYMERIZABLE COMPOUND AND OPTICAL ISOMER
  申请人：DIC Corporation

  公开号：US20180022716A1

  公开（公告）日：2018-01-25

  The present invention provides a polymerizable compound having high storage stability without causing crystal precipitation when added to a polymerizable composition. The present invention also provides a polymerizable composition containing the compound. When the filmy polymer produced through polymerization of the polymerizable composition is irradiated with UV light, it hardly discolors or peels from substrate. Further, the present invention provides a polymer produced through polymerization of the polymerizable composition and an optically anisotropic body using the polymer.

  本发明提供了一种聚合物化合物，具有高储存稳定性，添加到聚合物化合物时不会导致结晶沉淀。本发明还提供了含有该化合物的聚合物化合物。当通过聚合物化合物的聚合产生薄膜状聚合物时，若用紫外光照射，它几乎不会变色或脱落。此外，本发明提供了通过聚合物化合物的聚合产生的聚合物，以及使用该聚合物的光学各向异性体。
• RETARDATION PLATE AND CIRCULARLY POLARIZING PLATE
  申请人：DIC Corporation

  公开号：US20180031738A1

  公开（公告）日：2018-02-01

  A retardation plate is formed by laminating at least two retardation plates of a retardation plate 1 and a retardation plate 2, in which at least one of the retardation plate 1 and the retardation plate 2 is formed of a polymer of a polymerizable liquid crystal composition. It is possible to provide a retardation plate imparting a phase difference of ¼ wavelength over a wide wavelength region, a circularly polarizing plate having excellent anti-reflection performance over a wide wavelength region, and a display element or a light-emitting element having excellent visibility.
• POLYMERIZABLE COMPOSITION AND OPTICALLY ANISOTROPIC BODY USING SAME
  申请人：DIC Corporation

  公开号：US20180016502A1

  公开（公告）日：2018-01-18

  The present invention provides a polymerizable composition containing: a) a polymerizable compound having one or two or more polymerizable groups and satisfying formula (I) Re(450 nm)/Re(550 nm)<1.0; and  (I) b) an organic solvent having a solubility parameter (SP value) of 8.50 to 11.00 (cal/cm 3 ) 0.5 , a boiling point of 75 to 180° C., and an evaporation rate index of 20 to 700. The present invention also provides an optically anisotropic body, a retardation film, an antireflective film, and a liquid crystal display device that are produced using the polymerizable composition of the present invention. The polymerizable composition of the present invention is useful because it is excellent in solubility and has high storage stability that prevents the occurrence of precipitation of crystals. When the composition is polymerized to produce a film-shaped polymer, uneven application is less likely to occur while the liquid crystal alignment is maintained.
• POLYMERIZABLE COMPOSITION AND OPTICALLY ANISOTROPIC BODY
  申请人：DIC Corporation

  公开号：US20180037817A1

  公开（公告）日：2018-02-08

  The polymerizable composition prevents precipitation and the like of crystals and has high storage stability. A polymer compound is added to the polymerizable composition. In a case where a film-shaped polymer obtained by polymerizing the polymerizable composition is prepared, a tilt angle formed with an air interface is small, and glances of reflected light when a circularly polarizing plate is obtained by combining the polymer with a polarizing plate are removed. In addition, there is provided a polymer obtained by polymerizing the polymerizable composition, and an optically anisotropic body using the polymer. The polymerizable composition includes a reverse dispersible compound represented by General Formula (I), and a compound represented by General Formula (II).