4-[(4-ethoxy-phenyl)-thioacetyl]-morpholine | 4947-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[(4-ethoxy-phenyl)-thioacetyl]-morpholine
• 英文别名: 4-[(4-Aethoxy-phenyl)-thioacetyl]-morpholin；2-(4-Ethoxy-phenyl)-1-morpholin-4-yl-ethanethione；2-(4-ethoxyphenyl)-1-morpholin-4-ylethanethione
• CAS: 4947-83-5
• 化学式: C₁₄H₁₉NO₂S
• 分子量: 265.376
• InChiKey: HPURJWYUCHYERM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  53.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[(4-ethoxy-phenyl)-thioacetyl]-morpholine 在 sodium hydroxide 作用下， 生成 4-乙基氧丙基乙酸酯
  参考文献：
  名称：

  Krishnamurti; Seshadri, Journal Of Scientific and Industrial Research, 1954, vol. 13 B, p. 474

  摘要：

  DOI：
• 作为产物：
  描述：

  4-乙氧基苯乙酮 、 吗啉 在 sulfur 作用下， 反应 20.0h， 以47%的产率得到4-[(4-ethoxy-phenyl)-thioacetyl]-morpholine
  参考文献：
  名称：

  摘要：

  2-(Alkoxycarbonylmethylidene)-4-aryl-5- (dialkylamino)thiophen-3(2H)-ones were synthesized by condensation of N,N-(dialkyl)warylthioacetamides with dialkyl acetylenedicarboxylates. Intermediate substituted vinylic sulfides were isolated. When heated or in the presence of an acid or a base, they undergo cyclization into thiophenes.

  DOI：

  10.1023/a:1015868201847

文献信息

• Reactions of Thioamides and Selenoamides with Hydrazonoyl Chlorides Under Phase-Transfer Conditions. A Convenient Method of Preparation of δ²-1,3,4-Thiadiazolines and δ²-1,3,4-Selenadiazolines
  作者：M. L. Petrov、M. A. Abramov

  DOI：10.1080/10426509808545473

  日期：1998.2.1

  Reactions of enolizable thio- and selenoamides with hydrazonoyl chlorides in the presence of bases and phase-transfer catalysts result in 2-dialkylamino-Δ2-1,3,4-thia- and selenadiazolines. The reactions proceed through formation of corresponding enethiolates and eneselenolates. At 80°C 2-dialkylamino-Δ2-1,3,4-thia- and selenadiazolines eliminate dialkylamines, giving 2-ylidene-Δ2-1,3,4-thia- and selenadiazolines

  在碱和相转移催化剂的存在下，可烯醇化的硫代和硒代酰胺与腙酰氯的反应产生 2-二烷基氨基-Δ2-1,3,4-硫代-和硒二唑啉。反应通过形成相应的烯硫醇盐和烯醇盐而进行。在 80°C 下，2-二烷基氨基-Δ2-1,3,4-硫杂-和硒二唑啉消除二烷基胺，以良好的产率得到 2-亚基-Δ2-1,3,4-硫杂-和硒二唑啉。在碱和相转移催化剂的存在下，不可烯醇化硫代酰胺与腙酰氯的反应发生为源自腙酰氯的腈亚胺的 1,3-偶极环加成与 C=​​S 键，产生 Δ2-1,3,4-噻二唑啉。
• Abramov, M. A.; Galishev, V. A.; Petrov, M. L., Russian Journal of Organic Chemistry, 1993, vol. 29, # 11.1, p. 1805 - 1810
  作者：Abramov, M. A.、Galishev, V. A.、Petrov, M. L.

  DOI：——

  日期：——
• Reaction of (p-alkoxyphenyl)-acetothioamides with acetylene-dicarboxylic esters
  作者：M. F. Kosterina、T. V. Rybalova、Yu. V. Gatilov、Yu. Yu. Morzherin

  DOI：10.1007/s10593-009-0291-x

  日期：2009.4

  The condensation of p-methoxy(ethoxy)phenylacetothioamides with acetylenedicarboxylic esters leads to two condensation products, 2-(alkoxycarbonylmethylene)-4-(4-methoxy(ethoxy)phenyl)-5-morpho-lino-3H-thiophen-3-ones and 2-(alkoxycarbonylmethylene)-4-(4-methoxy(ethoxy)phenyl)-5-alkoxy-3H-thiophen-3-ones. It was shown that the substitution of the morpholino group is intramolecular.
• MNDZHOYAN O. L.; PAXLEVANYAN M. Z.; MELKONYAN D. A.; GERASIMYAN D. A., ARM. XIM. ZH. <AUKZ-AN>, 1974, 27, HO 12, 1051-1055
  作者：MNDZHOYAN O. L.、 PAXLEVANYAN M. Z.、 MELKONYAN D. A.、 GERASIMYAN D. A.

  DOI：——

  日期：——
• ——
  作者：M. F. Kosterina、Yu. Yu. Morzherin、A. V. Tkachev、T. V. Rybalova、Yu. V. Gatilov、V. A. Bakulev

  DOI：10.1023/a:1015868201847

  日期：——

  2-(Alkoxycarbonylmethylidene)-4-aryl-5- (dialkylamino)thiophen-3(2H)-ones were synthesized by condensation of N,N-(dialkyl)warylthioacetamides with dialkyl acetylenedicarboxylates. Intermediate substituted vinylic sulfides were isolated. When heated or in the presence of an acid or a base, they undergo cyclization into thiophenes.