N,N'-bis(4-ethoxyphenyl)ethanimidamide;hydron;chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N,N'-bis(4-ethoxyphenyl)ethanimidamide;hydron;chloride
• 化学式: C18H23ClN2O2
• 分子量: 334.8
• InChiKey: RRRKUSYYBYVFMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  42.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Compositions and methods for enhancing drug delivery across and into ocular tissues
  申请人：CellGate, Inc., a Delaware corporation

  公开号：US20030022831A1

  公开（公告）日：2003-01-30

  This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.

  这项发明提供了增强药物和其他药剂通过上皮组织传递的组合物和方法，包括进入和穿过眼组织等。这些组合物和方法也适用于穿过内皮组织，包括血脑屏障。这些组合物和方法利用了一种具有足够的瓜二或酰胺基侧链基团以增强与试剂结合的化合物穿过组织一层或多层的传递的传递增强转运体，与非结合化合物相比。传递增强聚合物包括，例如，多精氨酸分子，其长度在大约6到25个残基之间。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• Compositions and methods for treatment of premature ejaculation
  申请人：NexMed (Holdings) Inc.

  公开号：US20040241245A1

  公开（公告）日：2004-12-02

  Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C 1 to C 8 alcohol, an aliphatic C 8 to C 30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.

  提供了治疗早泄的组合物和方法，其中包括一种含有局部麻醉剂、剪切稀释聚合物增稠剂、选择自脂肪族C1到C8醇、脂肪族C8到C30酯、液态多元醇或其混合物的亲脂成分、水和缓冲系统的组合物，该缓冲系统为组合物提供了在约3至约7.4范围内的缓冲pH值，并将其用于阴茎尿道口。
• ALPROSTADIL AND DYCLONINE FOR TREATMENT OF PREMATURE EJACULATION
  申请人：NexMed Holdings, Inc.

  公开号：US20150011585A1

  公开（公告）日：2015-01-08

  Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C 1 to C 8 alcohol, an aliphatic C 8 to C 30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.

  本发明提供了用于治疗早泄的组合物和方法，其中包括一种含有局部麻醉剂、剪切稀释聚合物增稠剂、脂溶性成分（所选自脂肪族C1至C8醇、脂肪族C8至C30酯、液态多元醇或其混合物）、水和缓冲系统的组合物，其提供了在约3至约7.4之间的缓冲pH值，该组合物被施用于阴茎尿道口。