ethyl (6E,9E,12E)-octadeca-6,9,12-trienoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl (6E,9E,12E)-octadeca-6,9,12-trienoate
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.5
• InChiKey: MJLYTDAIYLGSRZ-NCEJYBGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] CARBOXYLIC ACID COMPOUND HAVING CYCLOPROPANE RING<br/>[FR] COMPOSE D'ACIDE CARBOXYLIQUE AYANT UN CYCLE DE CYCLOPROPANE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2002050013A1

  公开（公告）日：2002-06-27

  A carboxylic acid compound having cyclopropane ring(s) of the formula (I): wherein R is alkyl or alkenyl optionally having one or more 1,2-cyclopropylene in a carbon chain and/or optionally having cyclopropyl at the end of a chain,X is a single bond or alkylene, wherein the total number of carbon less the number of cyclopropane ring is 10-25, and a pharmaceutically acceptable salt thereof are provided. The compound (I) shows an LTP-like potentiation of synaptic transmission, allows slow metabolism in the living body, shows a stable LTP-like potentiation of synaptic transmission, and is useful as an agent for LTP-like potentiation of synaptic transmission, a cognition-enhancing drug or an agent for the prophylaxis and treatment of dementia, a learning and memory disorder and a neurotransmitter release disorder.

  提供一种具有环丙烷环的羧酸化合物的公式（I）：其中R是烷基或烯基，可选地具有一个或多个1,2-环丙烯基在碳链中和/或在链的末端可选地具有环丙基，X是单键或烷基，其中碳数减去环丙烷环的数量为10-25，并提供其药学上可接受的盐。化合物（I）表现出类似LTP的突触传递增强作用，可以在活体内缓慢代谢，表现出稳定的类似LTP的突触传递增强作用，并且可用作LTP样突触传递增强剂、增强认知药物或预防和治疗痴呆、学习和记忆障碍以及神经递质释放障碍的药剂。
• Carboxylic acid compound cyclopropane ring
  申请人：Nishizaki Tomoyuki

  公开号：US20050075393A1

  公开（公告）日：2005-04-07

  A carboxylic acid compound having cyclopropane ring(s) of the formula (I): wherein R is alkyl or alkenyl optionally having one or more 1,2-cyclopropylene in a carbon chain and/or optionally having cyclopropyl at the end of a chain, X is a single bond or alkylene, wherein the total number of carbon less the number of cyclopropane ring is 10-25, and a pharmaceutically acceptable salt thereof are provided. The compound (I) shows an LTP-like potentiation of synaptic transmission, allows slow metabolism in the living body, shows a stable LTP-like potentiation of synaptic transmission, and is useful as an agent for LTP-like potentiation of synaptic transmission, a cognition-enhancing drug or an agent for the prophylaxis and treatment of dementia, a learning and memory disorder and a neurotransmitter release disorder.

  提供一种具有环丙烷环的羧酸化合物的公式（I）：其中R是烷基或烯基，可选择在碳链中具有一个或多个1,2-环丙烯基和/或末端具有环丙基，X是单键或烷基，其中碳的总数减去环丙烷环的数量为10-25，并提供其药学上可接受的盐。化合物（I）显示出类似LTP的突触传递强化作用，在活体内代谢缓慢，显示出稳定的类LTP突触传递强化作用，并可用作LTP类突触传递强化剂、认知增强药物或预防和治疗痴呆症、学习和记忆障碍以及神经递质释放障碍的药物。
• USE OF CARBOXYLIC ACID COMPOUND HAVING CYCLOPROPANE RING AS MEDICAMENT
  申请人：Tox K.K.

  公开号：EP1343746B1

  公开（公告）日：2006-06-14
• CARBOXYLIC ACID COMPOUND HAVING CYCLOPROPANE RING
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1343746A1

  公开（公告）日：2003-09-17
• US7468389B2
  申请人：——

  公开号：US7468389B2

  公开（公告）日：2008-12-23