Acetic acid--1-(1H-indol-3-yl)propan-2-amine (1/1) | 5118-26-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetic acid--1-(1H-indol-3-yl)propan-2-amine (1/1)
• 英文别名: acetic acid;1-(1H-indol-3-yl)propan-2-amine
• CAS: 5118-26-3
• 化学式: C13H18N2O2
• 分子量: 234.29
• InChiKey: NMZSAMXFINECBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Depot Formulations
  申请人：Wright Jeremy C.

  公开号：US20080287464A1

  公开（公告）日：2008-11-20

  Disclosed are formulations and related methods that comprise a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity.

  揭示了包含非聚合物、非水溶性高粘度液体载体材料的配方和相关方法，该液体载体材料在37°C时的粘度至少为5,000 cP，在常温或生理条件下不会结晶；一种包含乳酸重复单元的特定线性聚合物；以及一个或多个具有溶剂容量的溶剂。
• Burn matrix, method of its preparation and delivery device comprising said matrix
  申请人：Key Pharmaceuticals, Inc.

  公开号：EP0040862A1

  公开（公告）日：1981-12-02

  This invention provides a burn matrix comprising glycerol, polyvinylalcohol, a water-soluble polymer having hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and water. The matrix may further include a drug for topical or transdermal application to a patient. The invention also provides a method of making the matrix and a delivery device incorporating the matrix. The matrix may be used in the form of a package, which comprises the matrix (14) embedded in a backing member (10) provided with a detachable cover layer (12). Before use, the cover layer is removed, and the backing member applied to the patient by means of a pressure-sensitive adhesive layer (26), so that the matrix (14) is held against the skin of the patient.

  本发明提供了一种烧伤基质，包括甘油、聚乙烯醇、一种具有水合位点的水溶性聚合物，该聚合物与其余成分结合可产生一种能够持续释放分散在其中的药物的基质，以及水。基质可进一步包括一种药物，供患者局部或透皮使用。本发明还提供了基质的制造方法和含有基质的给药装置。基质可以包装的形式使用，包装包括嵌入基质（14）的背衬件（10），背衬件上有可拆卸的覆盖层（12）。使用前，取下覆盖层，通过压敏胶层（26）将背衬件贴在患者身上，使基质（14）紧贴患者皮肤。
• Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
  申请人：Merck & Co., Inc.

  公开号：EP0100424A2

  公开（公告）日：1984-02-15

  The invention relates to the use of an acid anhydride incorporated as a latentiated catalyst in poly(ortho ester) and other polymers such that upon exposure to aqueous environments the acid anhydride generates the corresponding acid which catalyzes the matrix erosion. The releasing rate of a loaded drug or other beneficial substance incorporated into or surrounded by the poly(ortho ester) or other polymers can be controlled in that the drug is released as the poty(ortho ester)s or other polymer is eroded by action of the acid anhydride incorporated therein.

  本发明涉及使用酸酐作为聚（原生酯）和其他聚合物中的潜伏催化剂，使酸酐在暴露于水性环境时生成相应的酸，从而催化基质侵蚀。可以控制掺入聚（原生酯）或其他聚合物或被其包围的药物或其他有益物质的释放速度，因为药物是随着聚（原生酯）或其他聚合物在其中掺入的酸酐的作用下被侵蚀而释放出来的。
• A water and drug delivery system for suppository use
  申请人：Merck & Co., Inc.

  公开号：EP0147479A1

  公开（公告）日：1985-07-10

  (57) A drug delivery system designed to deliver water and drug to the site of administration is composed of a core (1) of an aqueous solubulizing system in a wax housing (2), which melts at body temperature, surrounded by a matrix (3) of drug and water-dispersible excipients. The entire unit may also be coated with a semi-permeable membrane (4) to modulate drug release.

  (57) 一种旨在将水和药物输送到给药部位的给药系统，由蜡壳（2）中的水溶性溶解系统核心（1）组成，蜡壳在体温下熔化，周围是药物和水分散性赋形剂基质（3）。 整个装置还可以涂上一层半透膜（4），以调节药物的释放。
• Poly(orthoester)polymers containing pendant acid functionalities and labile backbone bonds
  申请人：Merck & Co., Inc.

  公开号：EP0168277A1

  公开（公告）日：1986-01-15

  The instant invention is directed to a polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units. The instant invention is also directed to a controlled release device which comprises: (A) a polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units; and (B) a beneficial substance incorporated within or surrounded by the matrix of said polymer.

  本发明涉及一种聚合物，该聚合物每个重复单元至少有一个易溶骨架键，每一千个重复单元至少有一个酸官能团。 本发明还涉及一种控释装置，该装置包括：(A)聚合物，该聚合物每个重复单元至少有一个易溶骨架键，每一千个重复单元至少有一个酸官能团；以及(B)一种有益物质，该有益物质包含在所述聚合物的基质中或被其包围。