(S)-N-((3-(4-fluoro-3-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (S)-N-((3-(4-fluoro-3-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
• 英文别名: N-[[(5S)-3-(4-fluoro-3-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• 化学式: C₁₆H₂₀FN₃O₄
• 分子量: 337.351
• InChiKey: MRRGEAIXMWNTCP-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (S)-N-((3-(2-amino-4-fluoro-5-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide 在 盐酸 、 sodium nitrite 、 次磷酸 作用下， 以 水 为溶剂， 反应 1.0h， 以13%的产率得到(S)-N-((3-(4-fluoro-3-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
  参考文献：
  名称：

  [EN] NOVEL OXAZOLIDINONE COMPOUNDS
  [FR] NOUVEAUX COMPOSÉS OXAZOLIDINONE

  摘要：

  一种新的噁唑啉酮化合物（S）-N-((3-(4-氟-3-吗啉基苯基)-2-氧代噁唑啉-5-基)甲基)乙酰胺，化学式为-I，以及其制备方法。 化合物-I。

  公开号：

  WO2015068171A1

文献信息

• Novel Oxazolidinone Antibacterial Compound
  申请人：LEE PHARMA LIMITED

  公开号：US20160272597A1

  公开（公告）日：2016-09-22

  The invention relates to novel oxazolidinone compound. More particularly, the invention relates to novel [(S)—N-[[3-[4-fluoro-3-morpholino phenyl]-2-oxooxazolidin-5-yl] methyl] acetamide] compound of Formula-I which was disclosed in Indian Patent Application No. 5063/CHE/2013 and corresponding PCT/IN2014/000018. The compound is a broad spectrum antimicrobial agent effective against Multi-Drug Resistant S. Maltophilia pathogen and a large number of gram positive and gram negative pathogens. The compound has shown excellent biological activities against S. Maltophilia which has developed resistance against a large number of antibiotics including some of the known and widely used oxazolidinone derivatives.

  本发明涉及一种新型的噁唑烷酮化合物。更具体地说，本发明涉及公开于印度专利申请号5063/CHE/2013和相应的PCT/IN2014/000018中的新型[(S)-N-[[3-[4-氟-3-吗啡基苯基]-2-氧代噁唑烷-5-基]甲基]乙酰胺]化合物，该化合物是一种广谱抗微生物剂，对多重耐药S. Maltophilia病原体以及大量革兰氏阳性和阴性病原体具有有效作用。该化合物已经表现出对S. Maltophilia的优异生物活性，该病原体已经对包括一些已知和广泛使用的噁唑烷酮衍生物在内的大量抗生素产生了耐药性。
• NOVEL OXAZOLIDINONE ANTIBACTERIAL COMPOUND
  申请人：Lee Pharma Ltd.

  公开号：EP3065740A1

  公开（公告）日：2016-09-14
• US9573910B2
  申请人：——

  公开号：US9573910B2

  公开（公告）日：2017-02-21
• [EN] NOVEL OXAZOLIDINONE ANTIBACTERIAL COMPOUND<br/>[FR] NOUVEAU COMPOSÉ ANTIBACTÉRIEN D'OXAZOLIDINONE
  申请人：LEE PHARMA LTD

  公开号：WO2015068173A1

  公开（公告）日：2015-05-14

  The invention relates to novel oxazolidinone compound. More particularly, the invention relates to novel [(S)- N- [[3-[4-fluoro-3-morpholino phenyl]-2-oxooxazolidin-5-yl] methyl] acetamide] compound of Formula-I which was disclosed in Indian Patent Application No. 5063/CHE/2013 and corresponding PCT/IN2014/000018. The compound is a broad spectrum antimicrobial agent effective against Multi-Drug Resistant S. Maltophilia pathogen and a large number of gram positive and gram negative pathogens. The compound has shown excellent biological activities against S. Maltophilia which has developed resistance against a large number of antibiotics including some of the known and widely used oxazolidinone derivatives.
• [EN] NOVEL OXAZOLIDINONE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS OXAZOLIDINONE
  申请人：LEE PHARMA LTD

  公开号：WO2015068171A1

  公开（公告）日：2015-05-14

  A novel oxazolidinone compound (S)-N-((3-(4-fluoro-3-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide of formula -I and a process for the preparation thereof. Compound-I.

  一种新的噁唑啉酮化合物（S）-N-((3-(4-氟-3-吗啉基苯基)-2-氧代噁唑啉-5-基)甲基)乙酰胺，化学式为-I，以及其制备方法。 化合物-I。