calcium;trisodium;2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: calcium;trisodium;2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate
• 化学式: C14H18CaN3Na3O10
• 分子量: 497.35
• InChiKey: AYFCVLSUPGCQKD-UHFFFAOYSA-I

计算性质

• 辛醇/水分配系数(LogP)：
  -18.73
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  210
• 氢给体数：
  0
• 氢受体数：
  13

ADMET

毒理性

• 在妊娠和哺乳期间的影响

使用期间总结：本记录中的信息指的是作为诊断剂使用的锝 Tc 99m 五乙酸（锝 Tc 99m-二乙三胺五乙酸；锝 Tc 99m DTPA）。美国核能管理委员会的一个小组委员会建议，在给予所有锝 Tc 99m 诊断产品后，应停止哺乳24小时，以简化指导建议，尽管这个时间间隔可能比必要的要长。几个国际机构和组织表示，在通过静脉注射或吸入给予哺乳母亲1000 MBq（30 mCi）以下的Tc 99m DTPA后，不需要中断哺乳。然而，为了遵循将暴露“尽可能合理地降低”的原则，一些专家建议在给予放射性药物前哺乳婴儿，并在剂量后中断哺乳3到6小时，然后完全挤出一次乳汁并丢弃。如果母亲在检查前已经挤出并保存了乳汁，她可以在哺乳中断期间用它喂养婴儿。母亲在通常的临床剂量后不需要避免与婴儿密切接触。 担心乳汁中放射性水平的母亲可以要求在医院核医学科进行测试。当放射性达到安全水平时，她可以恢复哺乳。已经发布了一种测量乳汁放射性和确定母亲可以安全恢复哺乳的时间的方法。 对于在工作场所接触Tc 99m物质的哺乳母亲，除了适当的辐射防护措施外，不需要采取任何预防措施。 ◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。 ◉ 对泌乳和乳汁的影响：截至修订日期，没有找到相关的已发布信息。

◉ Summary of Use during Lactation:Information in this record refers to the use of technetium Tc 99m pentetate (Tc 99m-diethylenetriaminepentaacetic acid; Tc 99m DTPA) as a diagnostic agent. A US Nuclear Regulatory Commission subcommittee has recommended that nursing be discontinued for 24 hours after administration of all technetium Tc 99m diagnostic products to simplify guidance recommendations, although this time interval may be longer than necessary. Several international agencies and organizations state that breastfeeding need not be interrupted after administration of Tc 99m DTPA in doses up to 1000 MBq (30 mCi) intravenously or by inhalation to a nursing mother. However, to follow the principle of keeping exposure "as low as reasonably achievable", some experts recommend nursing the infant just before administration of the radiopharmaceutical and interrupting breastfeeding for 3 to 6 hours after the dose, then expressing the milk completely once and discarding it. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption. Mothers need not refrain from close contact with their infants after usual clinical doses. Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level, she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published. For nursing mothers who work with Tc 99m substances in their workplace, there is no need to take any precautions other than those appropriate for general radiation protection. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)

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