triazanium;iron(3+);oxalate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: triazanium;iron(3+);oxalate
• 化学式: C6H12FeN3O12
• 分子量: 374.02
• InChiKey: UEUDBBQFZIMOQJ-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -9.42
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  244
• 氢给体数：
  3
• 氢受体数：
  12

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测休克并视需要进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能够吞咽，有强烈的呕吐反射，且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。/铁及其相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. /Iron and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于失去意识的患者，考虑进行口咽或鼻咽气管插管以控制气道。监测心率和必要时治疗心律失常。开始静脉输液，使用乳酸钠林格氏液/生理盐水：为了保持开放，最低流量。注意液体过载的迹象。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象。使用丙美卡因氢氯化物协助眼部冲洗。/铁及其相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Iron and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

保持呼吸道通畅，必要时协助通气。积极使用静脉晶体液治疗由出血性胃肠炎引起的休克，并在需要时输血。由于胃肠道丢失和液体进入肠壁和间质空间的第三间隙，患者常常出现明显的低血容量。如果出现昏迷、癫痫和代谢性酸中毒，则进行治疗。对于严重中毒受害者（例如，休克、严重酸中毒和/或血清铁> 500-600 mcg/dL），给予去铁胺。监测尿液，以发现特征性的橙色或粉红色去铁胺-铁复合物。当尿液恢复正常或血清铁水平降至正常范围时，可以停止治疗。长期使用去铁胺与成人呼吸窘迫综合征和耶尔森菌血症有关。

Maintain an open airway and assist ventilation if necessary. Treat shock caused by hemorrhagic gastrointestinitis aggressively with intravenous crystalloid fluids, and replace blood if needed. Patients are often markedly hypovolemic owing to gastrointestinal losses and third spacing of fluids into the intestinal wall and interstitial space. Treat coma, seizures, and metabolic acidosis if they occur. For seriously intoxicated victims (eg, shock, severe acidosis, and/or serum iron > 500-600 mcg/dL) administer deferoxamine. Monitor the urine for the urine for the characteristic orange or pink deferoxamine-iron complex. Therapy may be stopped when the urine returns to normal or when the serum iron level decreases to the normal range. Prolonged deferoxamine has been associated with adult respiratory distress syndrome and Yersinia sepsis.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

活性炭无效。不建议使用吐根糖浆，因为它可能加剧铁剂引起的胃肠道刺激，并干扰整个肠道冲洗。如果产品是液体配方或片剂被嚼碎，考虑洗胃。不要使用含磷酸盐的溶液进行灌洗；这可能导致生命威胁性的高钠血症、高磷血症和低钙血症。碳酸氢盐和去铁胺灌洗的效果值得怀疑。去铁胺灌洗无效，可能增强铁的吸收。整个肠道冲洗对于吞入的片剂非常有效，可以被视为一线治疗方法，特别是如果普通腹部X光片上可见大量片剂。大量摄入可能导致凝结物或团块。重复或长时间的整个肠道冲洗可能移除片剂。内窥镜检查或外科胃切开术很少需要。

Activated charcoal is not effective. Ipecac is not recommended, because it can aggravate iron-induced gastrointestinal irritation and interfere with whole bowel irrigation. Consider gastric lavage if product was a liquid formulation or tablets were chewed. Do-not use phosphate-containing solutions for lavage; these may result in life-threatening hypernatremia, hyperphosphatemia, and hypocalcemia. Bicarbonate and deferoxamine lavage are of doubtful efficacy. Deferoxamine lavage is not effective and may enhance iron absorption. Whole-bowel irrigation is very effective for ingested tablets and may be considered first-line treatment, especially if large numbers of tablets are visible on plain abdominal x-ray. Massive ingestions may lead to concretions or bezoars. Repeated or prolonged whole-bowel irrigation may remove tablets. Endoscopy or surgical gastrotomy is rarely required.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  triazanium;iron(3+);oxalate 生成 Oxido(oxo)iron;oxoiron;oxoiron(1+)
  参考文献：
  名称：

  TOMITA, A.;OHTSUKA, Y.;TAKARADA, T.;NABATAME, T., XANLYAN XUASYUEH SYUEHBAO, 16,(1988) N 2, 111-117

  摘要：

  DOI：
• 作为产物：
  描述：

  草酸铵 、 草酸亚铁 生成 triazanium;iron(3+);oxalate
  参考文献：
  名称：

  RATAJEWICZ, ZBIGNIEW;SAWA, JOZEF

  摘要：

  DOI：

文献信息

• RATAJEWICZ, ZBIGNIEW;SAWA, JOZEF
  作者：RATAJEWICZ, ZBIGNIEW、SAWA, JOZEF

  DOI：——

  日期：——
• TOMITA, A.;OHTSUKA, Y.;TAKARADA, T.;NABATAME, T., XANLYAN XUASYUEH SYUEHBAO, 16,(1988) N 2, 111-117
  作者：TOMITA, A.、OHTSUKA, Y.、TAKARADA, T.、NABATAME, T.

  DOI：——

  日期：——