P-苯基硫代膦酸二酰肼 | 5395-21-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: P-苯基硫代膦酸二酰肼
• 英文名称: phenyl-phosphonothioic acid dihydrazide
• 英文别名: phenyl-thiophosphonic acid dihydrazide；Phenyl-thiophosphonsaeure-dihydrazid；Phosphonothioic dihydrazide, P-phenyl-；[hydrazinyl(phenyl)phosphinothioyl]hydrazine
• CAS: 5395-21-1
• 化学式: C₆H₁₁N₄PS
• 分子量: 202.22
• InChiKey: HDCICIWMRHHDMV-UHFFFAOYSA-N

物化性质

• 溶解度：
  0.04 M

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  5

上下游信息

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  ——	6,7-dimethyl-3-phenyl-3,4-dihydro-2H-[1,2,4,5,3]tetrazaphosphepine 3-sulfide	56818-62-3	C10H13N4PS	252.28

反应信息

• 作为反应物：
  描述：

  P-苯基硫代膦酸二酰肼 、 原苯甲酸三乙酯 在 溶剂黄146 作用下， 生成 3,6-diphenyl-1,2,3,4-tetrahydro-[1,2,4,5,3]tetrazaphosphinine 3-sulfide
  参考文献：
  名称：

  Majoral,J.P. et al., Journal of Heterocyclic Chemistry, 1977, vol. 14, p. 749 - 755

  摘要：

  DOI：
• 作为产物：
  描述：

  苯基硫代膦酰二氯 在 肼 作用下， 生成 P-苯基硫代膦酸二酰肼
  参考文献：
  名称：

  Nitrogen Compounds of the Phosphoric and Phosphonic Acids. II. Hydrazides of Phenylphosphonic and Phenylphosphonothionic Acids^1,2,3

  摘要：

  DOI：

  10.1021/jo01107a025

文献信息

• Grapov,A.F. et al., Journal of general chemistry of the USSR, 1977, vol. 47, p. 1560 - 1567
  作者：Grapov,A.F. et al.

  DOI：——

  日期：——
• Nitrogen Compounds of the Phosphoric and Phosphonic Acids. II. Hydrazides of Phenylphosphonic and Phenylphosphonothionic Acids^1,2,3
  作者：W. C. SMITH、RALPH GHER、L. F. AUDRIETH

  DOI：10.1021/jo01107a025

  日期：1956.1
• Phosphorus-nitrogen compounds. 20. Thiophosphorus hydrazones
  作者：L. A. Cates、Y. M. Cho、L. K. Smith、L. Williams、T. L. Lemke

  DOI：10.1021/jm00231a010

  日期：1976.9

  Six pyridine-2-carboxaldehyde, one pyridine N-oxide 2-carboxaldehyde, and five diketone thiophosphoric hydrazones, three thiophosphoric hydrazides, and two cupric chelates were synthesized. The chelates and nine of the hydrazones were tested against Ehrlich ascites carcinoma. Seven of these latter agents were administered concurrently with either cupric and/or ferrous salts to mice bearing this tumor. The greatest activity was found with the chelate, cimethyl pyridine-2-carboxyaldehyde phosphorothioic hydrazone-copper (1:1). The hydrazone portion of this chelate also formed a ligand-copper (2:1) complex. Although all of the hydrazones but one were inactive when evaluated alone, the concurrent injection of cupric ion increased survival times by an avoli alkaline phosphatase was found to be inhibited by two thiosemicarbazones in a manner similar to that previously reported by these agents against alkaline phosphatase derived from Sarcoma 180-6-thiopurine resistant ascites cells. None of the 14 hydrazides or hydrazones tested against E. coli enzyme displayed significant inhibition.
• Majoral,J.P. et al., Journal of Heterocyclic Chemistry, 1977, vol. 14, p. 749 - 755
  作者：Majoral,J.P. et al.

  DOI：——

  日期：——