Zinc(2+) NTA | 53113-57-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Zinc(2+) NTA
• 英文别名: zinc;2-[carboxylatomethyl(carboxymethyl)amino]acetate
• CAS: 53113-57-8
• 化学式: C6H7NO6Zn
• 分子量: 254.5
• InChiKey: OUZIZSDIHWTACR-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.13
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

毒理性

• 副作用

国际癌症研究机构致癌物-第3类：化学品无法被国际癌症研究机构分类。

IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 人类毒性摘录

NTA将锌带入肾小管超滤液，在那里它被肾小管上皮细胞重新吸收。锌对肾小管上皮细胞有毒，导致细胞损伤和死亡，进而引起细胞增生，最终可能导致肿瘤反应。

... NTA carries zinc into the renal tubular ultrafiltrate, where it is reabsorbed by the tubular epithelium. Zinc is toxic to ... /tubular epithelium/ cells, producing cell injury and death leading to a hyperplastic and eventually, neoplastic response.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

当正常受刺激培养的人淋巴细胞用各种可溶性锌盐预处理后，出现染色体碎片、二倍体、双中心体和染色单体间隙及断裂的细胞数量增加。后来的研究使用类似的治疗方案表明，锌以剂量依赖性方式降低了淋巴细胞的有丝分裂指数。/可溶性锌盐/

When normal stimulated cultured human lymphocytes were pretreated with various soluble zinc salts, there was an increase in the numbers of cells with chromosomal fragmentation, diploidy, dicentrism, and chromatid gaps and breaks. A later study using a similar treatment regimen indicated that zinc induced a dose-dependent decrease in lymphocytic mitotic indices. /Soluble zinc salts/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

静脉注射锌后，锌会分布到红细胞、血浆和白细胞中；血液中大约80%的锌存在于红细胞中，12-20%在血浆中，大约3%在白细胞中。血浆和红细胞之间存在锌的动态交换。吸入锌盐的尘埃会在肺部暂时积聚，然后被吸收到血液中。通过皮肤吸收的锌或其盐分很少。大约80%的静脉注射锌通过粪便排出，这表明锌有一个肠肝循环。在人体中，大约10%的吸收锌通过尿液排出，在热带气候中，每天大约有2-3毫克的锌通过汗水丢失。/可溶性锌化合物/

Upon intravenous injection zinc is distributed to erythrocytes, plasma, and leukocytes; about 80% of the zinc present in the blood is found in the erythrocytes, 12-20% in the plasma, and about 3% in the leukocytes. ... There is a dynamic exchange of zinc between plasma and erythrocytes. Inhalation of dusts of zinc salts results in a transient accumulation in the lung before its absorption into the blood. There is little absorption of zinc or its salts through the skin. ... About 80% of parenterally administered zinc is excreted in the feces, suggesting an enterohepatic circulation for zinc. In humans, about 10% of the absorbed zinc is excreted in the urine, and in tropical climates about 2-3 mg zinc/day may be lost in sweat. /Soluble zinc compounds/

来源:Hazardous Substances Data Bank (HSDB)