R(+)-舒必利 | 23756-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: R(+)-舒必利
• 中文别名: 舒必利
• 英文名称: (+)-(R)-sulpiride
• 英文别名: (+)-Sulpiride；N-[[(2R)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide
• CAS: 23756-79-8
• 化学式: C₁₅H₂₃N₃O₄S
• mdl: MFCD00069359
• 分子量: 341.431
• InChiKey: BGRJTUBHPOOWDU-LLVKDONJSA-N

物化性质

• 密度：
  1.236±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  舒必利 生成 R(+)-舒必利
  参考文献：
  名称：

  AL-KOUTAYNI-RIFAI, M.;JAMET, G.;KERR, R. R.;JUNG, L.;KOFFEL, J. C., J. LABELL. COMPOUNDS AND RADIOPHARM., 27,(1989) N, C. 811-821

  摘要：

  DOI：

文献信息

• METHODS AND SYSTEMS FOR DESIGNING AND/OR CHARACTERIZING SOLUBLE LIPIDATED LIGAND AGENTS
  申请人：TUFTS MEDICAL CENTER

  公开号：US20160052982A1

  公开（公告）日：2016-02-25

  The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.

  本申请提供了制备可溶性脂质化配体药剂的方法，包括配体实体和脂质实体，并在某些实施例中提供了这些组分的相关参数，从而使得能够适当选择组分来组装出针对任何感兴趣的靶点的活性药剂。
• Characteristic and complementary chiral recognition ability of four recently developed immobilized chiral stationary phases based on amylose and cellulose phenyl carbamates and benzoates
  作者：Takafumi Onishi、Takunori Ueda、Kenichi Yoshida、Kosuke Uosaki、Hiroyuki Ando、Ryota Hamasaki、Atsushi Ohnishi

  DOI：10.1002/chir.23446

  日期：2022.7

  various immobilized chiral stationary phases (CSPs) have been developed. The immobilized CSPs have opened up possibilities not only maintaining the high chiral recognition abilities as well as corresponding coated ones but also affording high durability to various mobile phase. This report directed to investigate enantioseparation of recently launched four immobilized CSPs with cellulose and amylose

  迄今为止，已经开发了各种固定化手性固定相 (CSP)。固定化的 CSP 不仅为保持高手性识别能力和相应的涂层能力开辟了可能性，而且为各种流动相提供了高耐久性。本报告旨在研究在正相液相色谱条件下最近推出的四种具有纤维素和直链淀粉骨架的固定化 CSP 的对映体分离。将它们的手性识别能力与之前开发的六种固定化 CSP 进行了比较。特别是，我们专注于手性识别的互补性。其中，直链淀粉三（3-氯-5-甲基苯基氨基甲酸酯）CSP，即CHIRALPAK IG，对各种外消旋体显示出显着的手性识别能力。正如预期的那样，研究的固定化 CSP 对各种流动相具有显着的耐久性，而相应的涂层 CSP 由于不可逆的降解而无法运行。利用不受限制的溶剂相容性，一些外消旋体的手性分离选择性得到改善。
• Methods and systems for designing and/or characterizing soluble lipidated ligand agents
  申请人：Tufts Medical Center

  公开号：US10233219B2

  公开（公告）日：2019-03-19

  The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.

  本申请提供了制备由配体实体和脂质实体组成的可溶性脂质配体制剂的方法，在某些实施方案中，还提供了这些成分中每种成分的相关参数，从而能够适当选择成分，为任何给定的感兴趣的靶标组装活性制剂。
• Synthesis and inhibitory activity on carbonic anhydrase of some new sulpiride analogs studied by means of a new method
  作者：Claudio Botre、Francesco Botre、Giancarlo Jommi、Roberto Signorini

  DOI：10.1021/jm00160a003

  日期：1986.10

  The pharmacological activity of several new sulpiride analogues was studied by means of a new approach, based on a potentiometric technique with a pCO2 sensor, capable of detecting carbonic anhydrase inhibition at equilibrium conditions. This procedure gives results stated as percent of inhibition of enzymatic activity (IP, inhibitory power). To prove the reliability of the proposed approach and to study structure-activity relationships, several new molecules were synthesized and tested in comparison with the two sulpiride enantiomers. A possible inhibition mechanism is discussed in terms of experimental evidence obtained from the interactions between the molecular structures of the new synthesized compounds and carbonic anhydrase.
• AL-KOUTAYNI-RIFAI, M.;JAMET, G.;KERR, R. R.;JUNG, L.;KOFFEL, J. C., J. LABELL. COMPOUNDS AND RADIOPHARM., 27,(1989) N, C. 811-821
  作者：AL-KOUTAYNI-RIFAI, M.、JAMET, G.、KERR, R. R.、JUNG, L.、KOFFEL, J. C.

  DOI：——

  日期：——