R(+)月桂K8644 | 98791-67-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: R(+)月桂K8644
• 中文别名: 钙离子通道抑制剂(BAY-K-8644 ((R)-(+)-))
• 英文名称: methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
• CAS: 98791-67-4
• 化学式: C16H15F3N2O4
• 分子量: 356.3
• InChiKey: ZFLWDHHVRRZMEI-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Direct reprogramming of cells to cardiac myocyte fate
  申请人：Duke University

  公开号：US10695378B2

  公开（公告）日：2020-06-30

  A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.

  一种促进细胞转化为心肌细胞组织的方法是通过将纤维组织（如疤痕组织）与 microRNA 寡核苷酸或 microRNA 寡核苷酸组合接触来实现的。这些方法可将成纤维细胞直接重编程为心肌细胞或心肌母细胞。
• Emergence of a R-type Ca²+ channel (Cav 2.3) contributes to cerebral artery constriction following subarachnoid hemorrhage
  申请人：Wellman C. George

  公开号：US20060229269A1

  公开（公告）日：2006-10-12

  The invention relates to methods and products for treatment of a neurological defect such as a subarachnoid hemorrhage or cerebral vasospasm. Specifically, R-type voltage-gated calcium channel inhibitors and related compositions and kits are described.

  本发明涉及治疗神经系统缺陷（如蛛网膜下腔出血或脑血管痉挛）的方法和产品。具体而言，本发明描述了 R 型电压门控钙通道抑制剂及相关组合物和试剂盒。
• DIRECT REPROGRAMMING OF CELLS TO CARDIAC MYOCYTE FATE
  申请人：Duke University

  公开号：EP2591095B1

  公开（公告）日：2016-04-27
• COMPOSITIONS AND METHODS FOR THE REPROGRAMMING OF CELLS INTO CARDIOMYOCYTES
  申请人：Duke University

  公开号：EP3177302A1

  公开（公告）日：2017-06-14
• Treatment of Subarachnoid Hemorrhage With APO E Analogs
  申请人：VITEK MICHAEL P.

  公开号：US20090131315A1

  公开（公告）日：2009-05-21

  Novel ApoE peptide derivatives and ApoE-protein transduction domain conjugates are disclosed which are useful for treating disorders including subarachnoid hemorrhage, intracerebral hemorrhage, and intraventricular hemorrhage and other brain disorders. The invention encompasses methods for treating cerebral vasospasm by administration of at least one ApoE or ApoE mimetic peptide.