Suxethonium | 67724-50-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Suxethonium
• 英文别名: ethyl-[2-[4-[2-[ethyl(dimethyl)azaniumyl]ethoxy]-4-oxobutanoyl]oxyethyl]-dimethylazanium
• CAS: 67724-50-9
• 化学式: C16H34N2O4+2
• 分子量: 318.45
• InChiKey: DIWYJMPVHQDIMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS AND METHODS FOR REDUCING, PREVENTING OR TREATING PAIN AND INFLAMMATION
  申请人：ZANELLA John

  公开号：US20090263489A1

  公开（公告）日：2009-10-22

  Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

  提供了治疗急性疼痛和/或炎症的有效方法，可以持续一段时间。通过在目标部位或附近给予足够的磺胺嘧啶，可以缓解由不同来源引起的疼痛，包括但不限于脊椎盘突出（即坐骨神经痛）、脊柱侧弯、狭窄、盘源性背痛和关节疼痛以及手术后的疼痛。当在可生物降解聚合物中提供适当的配方时，这种缓解可以持续至少三天。在某些实施例中，缓解可以持续至少25天、至少50天、至少100天、至少135天或至少180天。
• DRUG DEPOTS FOR TREATMENT OF PAIN AND INFLAMMATION IN SINUS AND NASAL CAVITIES OR CARDIAC TISSUE
  申请人：WALSH Andrew J. Lowenthal

  公开号：US20100239632A1

  公开（公告）日：2010-09-23

  Effective treatments of pain and/or inflammation are provided. Through the administration of a biodegradable drug depot film, patch, strip or sponge being implantable at or near a cardiac tissue or within a nasal or sinus cavity, one can reduce, prevent or treat pain and/or inflammation.

  提供有效的疼痛和/或炎症治疗。通过在心脏组织附近或鼻腔或鼻窦内植入可生物降解的药物沉积膜、贴片、条或海绵，可以减轻、预防或治疗疼痛和/或炎症。
• AN ORAL APPLIANCE FOR DELIVERY OF MEDICAMENTS AND/OR OTHER SUBSTANCES
  申请人：Zegarelli, Peter, J.

  公开号：EP3572028A1

  公开（公告）日：2019-11-27

  A computer implemented method is provided for making an oral appliance. A digital record of a patient's oral cavity is created by obtaining a baseline digital image of at least a portion of the teeth, and/or soft tissue of the oral cavity, using an imaging device. A first digital image (Dig1) of an oral appliance corresponding to the at least a portion of the teeth, and/or soft tissue of the oral cavity of the baseline image is obtained. A second digital image (Dig2) corresponding to at least a portion of the teeth and/or soft tissue of the oral cavity in need of treatment is created. The first digital image and the second digital image are combined to form a third digital image (Dig3) of the oral appliance that comprises the treatment area. The third digital image is stored in the computer.

  提供了一种用于制作口腔矫治器的计算机实现方法。通过使用成像设备获取至少一部分牙齿和/或口腔软组织的基线数字图像，创建患者口腔的数字记录。获得与基线图像中至少一部分牙齿和/或口腔软组织相对应的口腔矫治器的第一幅数字图像（Dig1）。创建与需要治疗的至少一部分牙齿和/或口腔软组织相对应的第二幅数字图像（Dig2）。将第一幅数字图像和第二幅数字图像合并，形成包含治疗区域的口腔装置的第三幅数字图像 (Dig3)。第三幅数字图像存储在计算机中。
• Oral appliance for delivering a medicament
  申请人：Zegarelli Peter John

  公开号：US10076393B2

  公开（公告）日：2018-09-18

  An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth. The oral appliance contains an interior surface having a medicament disposed in or on at least a portion of and/or the entire interior surface of the oral appliance. The interior surface of the oral cavity is formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the oral cavity and is configured for holding the medicament in contact with at least the portion of the teeth and/or soft tissue areas inside the oral cavity to deliver the medicament to strategic areas in need of treatment. In some embodiments, computer, network and computer readable storage media are provided.

  提供了一种口腔器械，用于向口腔内至少一部分牙齿和/或软组织区域输送药物。该口腔器械包含一个内表面，在该内表面的至少一部分和/或整个内表面上放置有药物。口腔内表面形成为适合口腔内至少部分牙齿和/或软组织区域的轮廓，并配置为将药物保持与口腔内至少部分牙齿和/或软组织区域接触，以将药物输送到需要治疗的战略区域。在一些实施例中，提供了计算机、网络和计算机可读存储介质。
• Oral appliance for delivery of medicaments and/or other substances
  申请人：Zegarelli Peter John

  公开号：US10238478B2

  公开（公告）日：2019-03-26

  An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth. The oral appliance contains an interior surface having a medicament disposed in or on at least a portion of and/or the entire interior surface of the oral appliance. The interior surface of the oral cavity is formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the oral cavity and is configured for holding the medicament in contact with at least the portion of the teeth and/or soft tissue areas inside the oral cavity to deliver the medicament to strategic areas in need of treatment. In some embodiments, computer, network and computer readable storage media are provided.

  提供了一种口腔器械，用于向口腔内至少一部分牙齿和/或软组织区域输送药物。该口腔器械包含一个内表面，在该内表面的至少一部分和/或整个内表面上放置有药物。口腔内表面形成为适合口腔内至少部分牙齿和/或软组织区域的轮廓，并配置为将药物保持与口腔内至少部分牙齿和/或软组织区域接触，以将药物输送到需要治疗的战略区域。在一些实施例中，提供了计算机、网络和计算机可读存储介质。