R-茚虫威 | 185608-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: R-茚虫威
• 英文名称: indoxacarb
• 英文别名: (R)-Indoxacarb；methyl (4aR)-7-chloro-2-[methoxycarbonyl-[4-(trifluoromethoxy)phenyl]carbamoyl]-3,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate
• CAS: 185608-75-7
• 化学式: C₂₂H₁₇ClF₃N₃O₇
• 分子量: 527.841
• InChiKey: VBCVPMMZEGZULK-OAQYLSRUSA-N

物化性质

• 沸点：
  571.4±60.0 °C(Predicted)
• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  在 哌啶 、 四磷十氧化物 作用下， 以 乙二醇二甲醚 、 1,2-二氯乙烷 为溶剂， 生成 R-茚虫威
  参考文献：
  名称：

  合成恶二嗪类杀虫剂茚虫威的新方法

  摘要：

  9-氟烯基甲氧羰基是化学工业中的良好保护基团。在本文中，一种新的合成恶二嗪类杀虫剂茚虫威的方法是使用9-芴基甲氧基羰基作为保护基，并用三光气进行氯甲酰化。9-芴基甲基氯甲酸酯和水合肼的亲核取代反应可以实现9-芴基甲氧基羰基肼的便捷合成。酮-肼交联可制得4a-甲基-2-（9-芴基甲基）-7-氯茚并[1,2e] [1,3,4]草二嗪2,4a（3H，5H）-二羧酸盐反应和环化。三光气的氯甲酰化可制得氨基甲酸-（氯羰基）-[（4-三氟甲氧基）苯基]甲酸酯。最后，9-芴基甲氧基羰基的脱保护和与氨基甲酸-（氯羰基）-[（4-三氟甲氧基）苯基]甲酸酯的缩合可以提供高收率的茚虫威。一种新的合成恶二嗪类杀虫剂茚虫威的新方法是使用9-芴基甲氧基羰基保护基生成9-芴基甲氧基羰基肼，然后通过酮-肼交联反应，环化，脱保护，氯甲酰化和缩合反应以高收率生产。

  DOI：

  10.1002/jhet.2449

文献信息

• Local topical administration formulations containing indoxacarb
  申请人：E. I. Du Pont de Nemours and Company

  公开号：EP2687093A1

  公开（公告）日：2014-01-22

  The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.

  本发明提供了用于控制家畜体外寄生虫的制剂和方法，使用的制剂包括茚虫威和兽医可接受的载体，该制剂局部施用在家畜总表面积的 10%或以下。其他实施方案包括这些制剂还包括一种或多种额外的杀虫剂，如氟虫腈。
• Comparative Study of the Selective Degradations of Two Enantiomers in the Racemate and an Enriched Concentration of Indoxacarb in Soils
  作者：Yu-Ping Zhang、De-Yu Hu、Hu-Rong Ling、Lei Zhong、An-Xiang Huang、Kan-Kan Zhang、Bao-An Song

  DOI：10.1021/jf5018803

  日期：2014.9.17

  In this study, selective degradations of the two enantiomers of indoxacarb in the concentrate (2.33S/1R) and racemate (1S/1 R) are examined. The absolute configurations of indoxacarb enantiomers were determined using X-ray diffraction. The results showed that in two alkaline soils, the S-(+)-indoxacarb was preferentially degraded in both the concentrate and racemate. In one acid soil, the two enantiomers degraded no-selectivity. In another acid soil and one neutral soil, the R-(-)-indoxacarb was preferentially degraded in both the concentrate and racemate. Indoxacarb enantiomers were configurationally stable in the five soils, and no interconversion was observed during the incubation. Because no significant difference in degradation was observed after samples were sterilized, the observed enantioselectivity may be attributed primarily to microbial activity in soils. The results indicate that the selective degradation behavior was the same for both formulations that were tested.
• INSECTICIDAL MIXTURES
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0888059B1

  公开（公告）日：1999-11-10
• FORMULATIONS CONTAINING INDOXACARB FOR LOCAL TOPICAL ADMINISTRATION
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2066179B1

  公开（公告）日：2016-06-22
• LOCAL TOPICAL ADMINISTRATION FORMULATIONS CONTAINING INDOXACARB
  申请人：E. I. du Pont de Nemours and Company

  公开号：US20130345210A1

  公开（公告）日：2013-12-26

  The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.