S-(羧甲基)-DL-高半胱氨酸 | 55593-14-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: S-(羧甲基)-DL-高半胱氨酸
• 英文名称: S-carboxymethyl-D,L-homocysteine
• 英文别名: S-carboxymethyl-DL-homocysteine；S-carboxymethyl-homocysteine；S-Carboxymethyl-DL-homocystein；DL-2-Amino-4-carboxymethylmercapto-buttersaeure；S-Carboxymethyl-homocystein；S-carboxymethylhomocysteine；2-Amino-4-(carboxymethylsulfanyl)butanoic acid
• CAS: 55593-14-1
• 化学式: C₆H₁₁NO₄S
• 分子量: 193.224
• InChiKey: BWLMCOKQHQOEEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 海关编码：
  2930909090

反应信息

• 作为产物：
  描述：

  DL-蛋氨酸 在 氨 、 sodium 作用下， 生成 S-(羧甲基)-DL-高半胱氨酸
  参考文献：
  名称：

  Stekol, Archives of Biochemistry, 1947, vol. 13, p. 128

  摘要：

  DOI：

文献信息

• Rationally engineered variants of S-adenosylmethionine (SAM) synthase: reduced product inhibition and synthesis of artificial cofactor homologues
  作者：M. Dippe、W. Brandt、H. Rost、A. Porzel、J. Schmidt、L. A. Wessjohann

  DOI：10.1039/c4cc08478k

  日期：——

  Rational redesign of bacterialS-adenosylmethionine-synthase by 3D-modelling and docking led to variants that allow synthesis of methylation cofactor SAM (AdoMet) without product inhibition, and of higher alkyl homologues.

  通过三维建模和对接，对细菌腺苷甲硫氨酸合成酶进行合理重设计，导致产生变种，可以合成甲基化辅酶SAM（AdoMet）而无产物抑制，并且可以合成更高级的烷基同系物。
• Peptide-polysaccharide-protein conjugate vaccines
  申请人：MERCK & CO. INC.

  公开号：EP0468714A2

  公开（公告）日：1992-01-29

  Covalent conjugate immunogens, having Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinant (PND) peptides covalently bound to the Outer Membrane Protein Complex (OMPC) of Neisseria through a linker which is an anionic polysaccharide (PSA), are useful for inducing anti-peptide immune responses in mammals, for inducing HIV-neutralizing antibodies in mammals, for formulating vaccines to prevent HIV infection or disease, including the Acquired Immune Deficiency Syndrome (AIDS) or for treating humans afflicted with HIV infection or HIV disease, including AIDS.

  人类免疫缺陷病毒（HIV）主要中和决定簇（PND）多肽通过阴离子多糖（PSA）连接体与奈瑟氏菌外膜蛋白质复合物（OMPC）共价结合的共价结合免疫原、可用于诱导哺乳动物的抗肽免疫反应、诱导哺乳动物的 HIV 中和抗体、配制疫苗以预防 HIV 感染或疾病（包括获得性免疫缺陷综合征（艾滋病））或治疗受 HIV 感染或 HIV 疾病（包括艾滋病）困扰的人类。
• Protein-dimeric polysaccharide conjugate vaccine
  申请人：MERCK & CO. INC.

  公开号：EP0534764A1

  公开（公告）日：1993-03-31

  A conjugate immunogen, having polysaccharide moieties derived from bacterial sources, provides a multivalent vaccine with a low protein to polysaccharide ratio. The vaccine reduces complications associated with injection of protein immunogens due to pyrogenic responses, such as swelling and pain, and is particularly suitable for administration to infants.

  共轭免疫原具有从细菌来源提取的多糖分子，可提供蛋白质与多糖比例较低的多价疫苗。这种疫苗减少了注射蛋白免疫原时因热原反应引起的并发症，如肿胀和疼痛，尤其适合婴儿接种。
• NOVEL MEDICAL USES OF THIOL-FUNCTIONALIZED POLYGLYCEROL DERIVATIVES
  申请人：Freie Universität Berlin

  公开号：EP3797783A1

  公开（公告）日：2021-03-31

  The invention relates to further medical uses of a polyglycerol derivative having a linear or dendritic polyglycerol backbone and carrying at least one thiol group covalently bound to the polyglycerol backbone, namely to its use as mucolytic; to its use in treating chronic sinusitis, asthma, chronic bronchitis, cystic fibrosis, chronic obstructive pulmonary disease, emphysema, or bronchiectasis; and to its use in treating chronic inflammatory bowel diseases, constipation, gastrointestinal malabsorption syndrome, irritable bowel syndrome, steatorrhea or diarrhea. The invention further relates to specific thiol-functionalized polyglycerol derivatives and to manufacturing methods for these polyglycerol derivatives.

  本发明涉及一种具有线性或树枝状聚甘油骨架并带有至少一个与聚甘油骨架共价结合的硫醇基团的聚甘油衍生物的进一步医疗用途，即用作粘液溶解剂；用于治疗慢性鼻窦炎、哮喘、慢性支气管炎、囊性纤维化、慢性阻塞性肺病、肺气肿或支气管扩张症；以及用于治疗慢性炎症性肠病、便秘、胃肠道吸收不良综合征、肠易激综合征、脂肪泻或腹泻。本发明还涉及特定的硫醇官能化聚甘油衍生物以及这些聚甘油衍生物的制造方法。
• 586. Some derivatives of S-carboxyalkyl-cysteines and -homocysteines
  作者：P. Mamalis、D. McHale、J. Green

  DOI：10.1039/jr9600002906

  日期：——