Dipotassium endothall | 2164-07-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Dipotassium endothall
• 英文别名: dipotassium;7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate
• CAS: 2164-07-0
• 化学式: C8H8O5.2K
• 分子量: 262.34
• InChiKey: ZPZKADHMBHMAES-UHFFFAOYSA-L

物化性质

• 物理描述：
  Dipotassium endothall appears as colorless crystals. Non-corrosive to metals. Used as an herbicide.
• 颜色/状态：
  The water solution is an amber liquid.
• 溶解度：
  In water, 1.228X10+6 mg/L at 20 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -8.71
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  5

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

这些除草剂的摄入可能会因刺激性特性而导致呕吐和腹泻。活性炭可能有效于限制刺激性影响并减少大多数或所有这些除草剂的吸收。铝氢氧化物抗酸剂可能有助于中和大多数酸性物质的刺激性作用。如果存在肠鸣音，且自发腹泻尚未开始，应给予山梨醇以诱导泻药。脱水和电解质紊乱可能严重到需要静脉输液。这些除草剂中毒没有特定的解毒剂。/其他除草剂/

Ingestions of these herbicides are likely to be followed by vomiting and diarrhea due to the irritant properties. ... Activated charcoal is probably effective in limiting irritant effects and reducing absorption of most or all of these herbicides. Aluminum hydroxide antacids may be useful in neutralizing the irritant actions of mose acidic agents. Sorbitol should be given to induce catharsis if bowel sounds are present and if spontaneous diarrhea has not already commenced. Dehydration and electrolyte disturbances may be severe enough to require intravenous fluids. There are no specific antidotes for poisoning by these herbicides. /Other Herbicides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

如果咽喉有腐蚀作用的迹象，由于食管穿孔的风险，不应尝试胃管插管。可能需要采取适合吞食腐蚀性物质（强酸强碱）的治疗程序。/内皮素/

If there are indications of corrosive effect in the pharynx, gastric intubation should not be attempted because of the risk of esophageal perforation. Treatment procedures appropriate for ingestion of corrosives (strong acids alkalis) may be necessary. /Endothall/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

氧气应通过面罩给予。如果呼吸驱动弱，可能需要机械支持肺通气。密切监测血压。可能需要输注血浆、血液、其他容量扩张剂和升压药来对抗休克。静脉输液以纠正脱水，稳定电解质，提供糖分，并支持毒物处置机制。/Endothall/

Oxygen should be given by mask. If respiratory drive is weak, pulmonary ventilation may have to be supported mechanically. Monitor blood pressure closely. Infusions of plasma, blood, other volume expanders, and pressors may be needed to combat shock. Administer intravenous fluids to correct dehydration, stabilize electrolytes, provide sugar, and support mechanisms for toxicant disposition. /Endothall/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

在考虑可能的心肌病情况下，非常小心地给予血管活性胺。癫痫发作可能需要使用地西泮和/或其他抗惊厥药物。/endothall/

Give vasoactive amines very carefully in light of possible myocardiopathy. Seizures may require administration of diazepam and/or other anticonvulsants. /Endothall/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

/Endothall/ 通过磨损的皮肤和胃肠道吸收良好。

/Endothall/ is well absorbed across abraded skin and from the gastrointestinal tract.

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• Methods and compositions for increasing the efficacy of biologically-active ingredients
  申请人：Windsor Brian J.

  公开号：US20060276339A1

  公开（公告）日：2006-12-07

  The invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, compositions are provided comprising combinations of ectophosphatase inhibitors and active agents. Active agents include antibiotics, fungicides, herbicides, insecticides, chemotherapeutic agents, and plant growth regulators. By increasing the efficacy of active agents, the invention allows use of compositions with lowered concentrations of active ingredients.